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Cops5 Gene Detail
Summary
  • Symbol
    Cops5
  • Name
    COP9 signalosome subunit 5
  • Synonyms
    COP9 complex S5, CSN5, Jab1, JUN activation binding protein, Sgn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349415
    NCBI Gene: 26754
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:10094825-10108384 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 2.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    548 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349415
 protein coding gene Chr1:10094825-10108393 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015832
 protein coding gene Chr1:7289431-7304118 (-)
A/J MGP_AJ_G0015814
 protein coding gene Chr1:7346213-7359776 (-)
AKR/J MGP_AKRJ_G0015773
 protein coding gene Chr1:7235316-7249011 (-)
BALB/cJ MGP_BALBcJ_G0015770
 protein coding gene Chr1:7079155-7092718 (-)
C3H/HeJ MGP_C3HHeJ_G0015604
 protein coding gene Chr1:7159296-7172855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016224
 protein coding gene Chr1:7628986-7642546 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013945
 protein coding gene Chr1:6183529-6202661 (-)
CAST/EiJ MGP_CASTEiJ_G0015184
 protein coding gene Chr1:7350654-7364177 (-)
CBA/J MGP_CBAJ_G0015577
 protein coding gene Chr1:7800144-7815016 (-)
DBA/2J MGP_DBA2J_G0015676
 protein coding gene Chr1:6965394-6978955 (-)
FVB/NJ MGP_FVBNJ_G0015681
 protein coding gene Chr1:6880053-6893624 (-)
LP/J MGP_LPJ_G0015748
 protein coding gene Chr1:7503308-7516871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015700
 protein coding gene Chr1:8456668-8470236 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016270
 protein coding gene Chr1:7139447-7153010 (-)
PWK/PhJ MGP_PWKPhJ_G0014968
 protein coding gene Chr1:6833149-6847101 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014748
 protein coding gene Chr1:7305363-7319079 (-)
WSB/EiJ MGP_WSBEiJ_G0015248
 protein coding gene Chr1:7173121-7186692 (-)



Homology
more
  • Human Ortholog
    COPS5, COP9 signalosome subunit 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPS5, COP9 signalosome subunit 5
  • Synonyms
    CSN5, JAB1, MOV-34, SGN5
  • Links
    NCBI Gene ID: 10987
    neXtProt AC: NX_Q92905
    UniProt: Q92905

  • Chr Location
    8q13.1; chr8:67043079-67083783 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die soon after implantation and exhibit growth-retardation, decrease in cell proliferation, and an increase in cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    928
  • Tissues
    120
  • cDNA Data
    163
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26754 NCBI Gene Model | MGI Sequence Detail 13560 C57BL/6J ±  kb
    transcript NR_102282 RefSeq | MGI Sequence Detail 1739 ZRU/MplStud  
    polypeptide O35864 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 165
      cDNA 164
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138191
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:58902 Asano K, et al., Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. J Biol Chem. 1997 Oct 24;272(43):27042-52
    • Latest
      J:333768 Maeoka Y, et al., Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice. J Am Soc Nephrol. 2022 Mar;33(3):584-600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory