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Cspg5 Gene Detail
Summary
  • Symbol
    Cspg5
  • Name
    chondroitin sulfate proteoglycan 5
  • Synonyms
    CALEB, neuroglycan C, NGC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352747
    NCBI Gene: 29873
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:110072851-110091644 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352747
 protein coding gene Chr9:110072851-110091644 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035343
 protein coding gene Chr9:112382168-112398194 (+)
A/J MGP_AJ_G0035324
 protein coding gene Chr9:108299674-108317505 (+)
AKR/J MGP_AKRJ_G0035255
 protein coding gene Chr9:110988757-111004764 (+)
BALB/cJ MGP_BALBcJ_G0035319
 protein coding gene Chr9:108043283-108059264 (+)
C3H/HeJ MGP_C3HHeJ_G0035027
 protein coding gene Chr9:111484331-111502225 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035841
 protein coding gene Chr9:115430530-115446613 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032727
 protein coding gene Chr9:105526369-105542410 (+)
CAST/EiJ MGP_CASTEiJ_G0034333
 protein coding gene Chr9:111275252-111292085 (+)
CBA/J MGP_CBAJ_G0034994
 protein coding gene Chr9:119730254-119746025 (+)
DBA/2J MGP_DBA2J_G0035153
 protein coding gene Chr9:107762343-107779881 (+)
FVB/NJ MGP_FVBNJ_G0035100
 protein coding gene Chr9:106587577-106603378 (+)
LP/J MGP_LPJ_G0035232
 protein coding gene Chr9:112681038-112697903 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035140
 protein coding gene Chr9:121091244-121108265 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035861
 protein coding gene Chr9:111307763-111326250 (+)
PWK/PhJ MGP_PWKPhJ_G0034040
 protein coding gene Chr9:108000854-108016825 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033875
 protein coding gene Chr9:111393957-111410125 (+)
WSB/EiJ MGP_WSBEiJ_G0034454
 protein coding gene Chr9:111191848-111207598 (+)



Homology
more
  • Human Ortholog
    CSPG5, chondroitin sulfate proteoglycan 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSPG5, chondroitin sulfate proteoglycan 5
  • Synonyms
    NGC
  • Links
    NCBI Gene ID: 10675
    neXtProt AC: NX_O95196
    UniProt: O95196

  • Chr Location
    3p21.31; chr3:47562238-47580792 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased spontaneous postsynaptic currents, increased paired-pulse ratios, and reduced long term depression during early postnatal developmental stages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    31
  • cDNA Data
    23
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29873 NCBI Gene Model | MGI Sequence Detail 18794 C57BL/6J ±  kb
    transcript NM_001166273 RefSeq | MGI Sequence Detail 3881 C57BL/6  
    polypeptide Q71M36 UniProt | EBI | MGI Sequence Detail 566 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005954 chondroitin sulfate proteoglycan 5
      (term hierarchy)
    • InterPro Domains
      IPR042382 Chondroitin sulfate proteoglycan 5
      IPR010555 CSPG5, sulphate attachment domain
      IPR009505 Neural chondroitin sulphate proteoglycan cytoplasmic
    • GlyGen
      Q71M36 16 sites, 7 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143104
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:59346 Aono S, et al., Genomic organization and expression pattern of mouse neuroglycan C in the cerebellar development. J Biol Chem. 2000 Jan 7;275(1):337-42
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory