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Timm8a1 Gene Detail
Summary
  • Symbol
    Timm8a1
  • Name
    translocase of inner mitochondrial membrane 8A1
  • Synonyms
    Ddp1, DXHXS1274E, Fci-12, Tim8a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353433
    NCBI Gene: 30058
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:133438005-133442419 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 56.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353433
 protein coding gene ChrX:133438005-133442614 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036069
 protein coding gene ChrX:131718205-131723885 (-)
A/J MGP_AJ_G0027292
 protein coding gene Chr3:79788822-79789814 (+)
AKR/J MGP_AKRJ_G0035970
 protein coding gene ChrX:135352250-135357112 (-)
BALB/cJ MGP_BALBcJ_G0036042
 protein coding gene ChrX:129572281-129578739 (-)
C3H/HeJ MGP_C3HHeJ_G0035722
 protein coding gene ChrX:116803046-116804210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036564
 protein coding gene ChrX:135608974-135613670 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0035033
 protein coding gene ChrX:112669463-112674085 (-)
CBA/J MGP_CBAJ_G0035723
 protein coding gene ChrX:139672250-139676288 (-)
DBA/2J MGP_DBA2J_G0035876
 protein coding gene ChrX:130449244-130453818 (-)
FVB/NJ MGP_FVBNJ_G0035818
 protein coding gene ChrX:129775427-129779787 (-)
LP/J MGP_LPJ_G0035969
 protein coding gene ChrX:132596462-132601044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035846
 protein coding gene ChrX:147023822-147031880 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036593
 protein coding gene ChrX:131150193-131155884 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0035170
 protein coding gene ChrX:129515878-129520475 (-)



Homology
more
  • Human Ortholog
    TIMM8A, translocase of inner mitochondrial membrane 8A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMM8A, translocase of inner mitochondrial membrane 8A
  • Synonyms
    DDP, DDP1, DFN1, MTS, TIM8
  • Links
    NCBI Gene ID: 1678
    neXtProt AC: NX_O60220
    UniProt: O60220

  • Chr Location
    Xq22.1; chrX:101345661-101348742 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TIMM8A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    16
  • cDNA Data
    66
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30058 NCBI Gene Model | MGI Sequence Detail 4415 C57BL/6J ±  kb
    transcript NM_013898 RefSeq | MGI Sequence Detail 1243 ZRU/MplStud  
    polypeptide Q9WVA2 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 1
      cDNA 66
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1201786
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:39674 Oeltjen JC, et al., Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Genome Res. 1997 Apr;7(4):315-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory