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Patz1 Gene Detail
Summary
  • Symbol
    Patz1
  • Name
    POZ (BTB) and AT hook containing zinc finger 1
  • Synonyms
    8430401L15Rik, MAZR, POZ-AT hook-zinc finger protein, Zfp278
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891832
    NCBI Gene: 56218
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3239131-3259083 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    376 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891832
 protein coding gene Chr11:3238874-3259083 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017954
 protein coding gene Chr11:138406-158487 (+)
A/J MGP_AJ_G0017927
 protein coding gene Chr11:202099-222101 (+)
AKR/J MGP_AKRJ_G0017891
 protein coding gene Chr11:205560-227699 (+)
BALB/cJ MGP_BALBcJ_G0017895
 protein coding gene Chr11:173764-194816 (+)
C3H/HeJ MGP_C3HHeJ_G0017708
 protein coding gene Chr11:146951-170771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018348
 protein coding gene Chr11:200136-224512 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016007
 protein coding gene Chr11:117966-138689 (+)
CAST/EiJ MGP_CASTEiJ_G0017270
 protein coding gene Chr11:94816-118383 (+)
CBA/J MGP_CBAJ_G0017683
 protein coding gene Chr11:370239-395169 (+)
DBA/2J MGP_DBA2J_G0017794
 protein coding gene Chr11:123596-144345 (+)
FVB/NJ MGP_FVBNJ_G0017785
 protein coding gene Chr11:149316-169643 (+)
LP/J MGP_LPJ_G0017864
 protein coding gene Chr11:244606-264933 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017811
 protein coding gene Chr11:127649-148315 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018387
 protein coding gene Chr11:213520-233715 (+)
PWK/PhJ MGP_PWKPhJ_G0017050
 protein coding gene Chr11:97153-117771 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016846
 protein coding gene Chr11:170078-191106 (+)
WSB/EiJ MGP_WSBEiJ_G0017324
 protein coding gene Chr11:92640-114473 (+)



Homology
more
  • Human Ortholog
    PATZ1, POZ/BTB and AT hook containing zinc finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PATZ1, POZ/BTB and AT hook containing zinc finger 1
  • Synonyms
    dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG
  • Links
    NCBI Gene ID: 23598
    neXtProt AC: NX_Q9HBE1
    UniProt: Q9HBE1

  • Chr Location
    22q12.2; chr22:31325804-31346346 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some embryonic and fetal lethality, exencephaly, nervous system defects, outflow defects, transposition of great arteries, postnatal growth retardation and male and female infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1231
  • Tissues
    282
  • cDNA Data
    15
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56218 NCBI Gene Model | MGI Sequence Detail 19953 C57BL/6J ±  kb
    transcript NM_001253691 RefSeq | MGI Sequence Detail 3210 C57BL/6  
    polypeptide Q5NBY9 UniProt | EBI | MGI Sequence Detail 687 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921776, MGI:2144162
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:64686 Kobayashi A, et al., A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Mol Cell Biol. 2000 Mar;20(5):1733-46
    • Latest
      J:353996 Ortabozkoyun H, et al., Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries. Mol Cell. 2024 Aug 19;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory