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Ifitm3 Gene Detail
Summary
  • Symbol
    Ifitm3
  • Name
    interferon induced transmembrane protein 3
  • Synonyms
    1110004C05Rik, Fgls, fragilis, IP15, mil-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913391
    NCBI Gene: 66141
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140589503-140590657 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.25 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913391
 protein coding gene Chr7:140589499-140590683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033205
 protein coding gene Chr7:146159754-146160938 (-)
A/J MGP_AJ_G0033187
 protein coding gene Chr7:141997387-141998571 (-)
AKR/J MGP_AKRJ_G0033119
 protein coding gene Chr7:145898762-145899952 (-)
BALB/cJ MGP_BALBcJ_G0033188
 protein coding gene Chr7:141734547-141735731 (-)
C3H/HeJ MGP_C3HHeJ_G0032902
 protein coding gene Chr7:145648605-145649789 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033699
 protein coding gene Chr7:151507517-151508701 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030672
 protein coding gene Chr7:143206823-143207992 (-)
CAST/EiJ MGP_CASTEiJ_G0032232
 protein coding gene Chr7:137954097-137957510 (-)
CBA/J MGP_CBAJ_G0032874
 protein coding gene Chr7:156620888-156622072 (-)
DBA/2J MGP_DBA2J_G0033027
 protein coding gene Chr7:139945857-139947041 (-)
FVB/NJ MGP_FVBNJ_G0032979
 protein coding gene Chr7:139847524-139848708 (-)
LP/J MGP_LPJ_G0033121
 protein coding gene Chr7:147659982-147661166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033012
 protein coding gene Chr7:157301135-157302319 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033719
 protein coding gene Chr7:144877554-144878738 (-)
PWK/PhJ MGP_PWKPhJ_G0031936
 protein coding gene Chr7:133209806-133210987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031783
 protein coding gene Chr7:131698568-131699760 (-)
WSB/EiJ MGP_WSBEiJ_G0032343
 protein coding gene Chr7:145821211-145822401 (-)



Homology
more
  • Human Ortholog
    IFITM3, interferon induced transmembrane protein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFITM3, interferon induced transmembrane protein 3
  • Synonyms
    1-8U, DSPA2b, IP15
  • Links
    NCBI Gene ID: 10410
    neXtProt AC: NX_Q01628
    UniProt: Q01628

  • Chr Location
    11p15.5; chr11:319676-329475 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IFITM3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    114
  • cDNA Data
    163
  • Literature Summary
    30
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66141 NCBI Gene Model | MGI Sequence Detail 1155 C57BL/6J ±  kb
transcript NM_025378 RefSeq | MGI Sequence Detail 648 C57BL/6  
polypeptide Q9CQW9 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007593 CD225/Dispanin family
    IPR051517 Interferon-induced transmembrane antiviral protein
  • GlyGen
    Q9CQW9 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 172
    cDNA 164
    Primer pair 4
    Other 4

    Microarray probesets 3
References
more
  • Summaries
    All 102
    Developmental Gene Expression 30
    Gene Ontology 11
    Phenotypes 37
  • Earliest
    J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
  • Latest
    J:351151 Liu X, et al., FOXP3(+) regulatory T cell perturbation mediated by the IFNgamma-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity. Nat Commun. 2024 Jan 2;15(1):122
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory