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Rpl3l Gene Detail
Summary
  • Symbol
    Rpl3l
  • Name
    ribosomal protein L3-like
  • Synonyms
    1110057H16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913461
    NCBI Gene: 66211
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24946800-24955117 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.52 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    318 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913461
 protein coding gene Chr17:24946794-24955117 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023320
 protein coding gene Chr17:23742541-23752873 (+)
A/J MGP_AJ_G0023280
 protein coding gene Chr17:23092493-23101978 (+)
AKR/J MGP_AKRJ_G0023247
 protein coding gene Chr17:23171422-23179948 (+)
BALB/cJ MGP_BALBcJ_G0023285
 protein coding gene Chr17:23289745-23300068 (+)
C3H/HeJ MGP_C3HHeJ_G0023045
 protein coding gene Chr17:23535106-23543529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023728
 protein coding gene Chr17:24793753-24803033 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021203
 protein coding gene Chr17:20559996-20568549 (+)
CAST/EiJ MGP_CASTEiJ_G0022547
 protein coding gene Chr17:23389653-23398093 (+)
CBA/J MGP_CBAJ_G0023021
 protein coding gene Chr17:25648127-25656641 (+)
DBA/2J MGP_DBA2J_G0023150
 protein coding gene Chr17:22685429-22694333 (+)
FVB/NJ MGP_FVBNJ_G0023120
 protein coding gene Chr17:22404675-22413347 (+)
LP/J MGP_LPJ_G0023227
 protein coding gene Chr17:24050923-24061265 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023139
 protein coding gene Chr17:25338537-25348588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023766
 protein coding gene Chr17:23454324-23463000 (+)
PWK/PhJ MGP_PWKPhJ_G0022296
 protein coding gene Chr17:21432153-21440809 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022117
 protein coding gene Chr17:21637700-21642051 (-)
WSB/EiJ MGP_WSBEiJ_G0022610
 protein coding gene Chr17:23527580-23537005 (+)



Homology
more
  • Human Ortholog
    RPL3L, ribosomal protein L3 like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL3L, ribosomal protein L3 like
  • Synonyms
    CMD2D
  • Links
    NCBI Gene ID: 6123
    neXtProt AC: NX_Q92901
    UniProt: Q92901

  • Chr Location
    16p13.3; chr16:1943974-1957606 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RPL3L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a reduction in heart weight with age. Another null allele shows reduced cardiac muscle contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66211 NCBI Gene Model | MGI Sequence Detail 8318 C57BL/6J ±  kb
    transcript NM_001163945 RefSeq | MGI Sequence Detail 1369 C57BL/6  
    polypeptide E9PWZ3 UniProt | EBI | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014227 ribosomal protein uL3-like
      (term hierarchy)
    • InterPro Domains
      IPR000597 Large ribosomal subunit protein uL3
      IPR045077 Large ribosomal subunit protein uL3, archaeal/eukaryotic-type
      IPR019926 Large ribosomal subunit protein uL3, conserved site
      IPR044892 Ribosomal protein L3, domain 3, archaeal-type superfamily
      IPR009000 Translation protein, beta-barrel domain superfamily
    • GlyGen
      E9PWZ3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:346291 Bajpai AK, et al., Exploring the Regulation and Function of Rpl3l in the Development of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure Using Systems Genetics Approach. Genes (Basel). 2023 Dec 29;15(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory