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H2bc4 Gene Detail
Summary
  • Symbol
    H2bc4
  • Name
    H2B clustered histone 4
  • Synonyms
    2610022J01Rik, H2bfs, Hist1h2bc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915274
    NCBI Gene: 68024
  • Member of
    Hist1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23868182-23876805 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.87 cM, cytoband A2-A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    394 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915274
 protein coding gene Chr13:23868182-23876891 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020355
 protein coding gene Chr13:21117647-21126410 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0020287
 protein coding gene Chr13:20984691-20993394 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0020108
 protein coding gene Chr13:21052554-21061870 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0018327
 protein coding gene Chr13:19517517-19525629 (+)
CAST/EiJ MGP_CASTEiJ_G0019625
 protein coding gene Chr13:20735912-20744338 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0020187
 protein coding gene Chr13:20263033-20271536 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0020259
 protein coding gene Chr13:21428779-21438430 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020199
 protein coding gene Chr13:23043964-23054716 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020781
 protein coding gene Chr13:20833742-20842809 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    H2BC10, H2B clustered histone 10
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2BC10, H2B clustered histone 10
  • Synonyms
    H2BC4, H2BC6, H2BC7, H2BC8, H2BFK, H2B/k, HIST1H2BI
  • Links
    NCBI Gene ID: 8346
    neXtProt AC: NX_P62807
    UniProt: P62807

  • Chr Location
    6p22.2; chr6:26272931-26273412 (+)  GRCh38
  • Human Ortholog
    H2BC5, H2B clustered histone 5
  • Synonyms
    dJ221C16.6, H2B.1B, H2B/a, H2B/b, H2BFA, H2BFB, H2BFG, H2BFH, H2BFK, H2BFL, H2B/g, H2B/h, H2B/k, H2B/l, HIRIP2, HIST1H2BC, HIST1H2BD, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI
  • Links
    NCBI Gene ID: 3017
    neXtProt AC: NX_P58876, NX_P62807
    UniProt: P58876

  • Chr Location
    6p22.2; chr6:26158121-26171349 (+)  GRCh38
  • Human Ortholog
    H2BC6, H2B clustered histone 6
  • Synonyms
    dJ221C16.8, H2BC10, H2BC4, H2BC7, H2BC8, H2BFH, H2B.h, H2B/h, HIST1H2BE
  • Links
    NCBI Gene ID: 8344
    neXtProt AC: NX_P62807
    UniProt: P62807

  • Chr Location
    6p22.2; chr6:26172059-26184655 (+)  GRCh38
  • Human Ortholog
    H2BC8, H2B clustered histone 8
  • Synonyms
    dJ221C16.8, H2B.1A, H2B/a, H2BC10, H2BC4, H2BC6, H2BC7, H2BFA, HIST1H2BG
  • Links
    NCBI Gene ID: 8339
    neXtProt AC: NX_P62807
    UniProt: P62807

  • Chr Location
    6p22.2; chr6:26216200-26216688 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    154
  • cDNA Data
    134
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68024 NCBI Gene Model | MGI Sequence Detail 8624 C57BL/6J ±  kb
    transcript NM_023422 RefSeq | MGI Sequence Detail 728 C57BL/6  
    polypeptide NP_001277309 RefSeq | MGI Sequence Detail 126 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 138
      Genomic 1
      cDNA 134
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145542, MGI:6324972
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Gene Ontology 1
      Phenotypes 15
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory