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Zfp251 Gene Detail
Summary
  • Symbol
    Zfp251
  • Name
    zinc finger protein 251
  • Synonyms
    9130001M19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918841
    NCBI Gene: 71591
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76736331-76755635 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    756 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918841
 protein coding gene Chr15:76735809-76755635 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022013
 protein coding gene Chr15:76967489-76988413 (-)
A/J MGP_AJ_G0021971
 protein coding gene Chr15:74139531-74161304 (-)
AKR/J MGP_AKRJ_G0021954
 protein coding gene Chr15:76159618-76181066 (-)
BALB/cJ MGP_BALBcJ_G0021980
 protein coding gene Chr15:74164755-74183934 (-)
C3H/HeJ MGP_C3HHeJ_G0021752
 protein coding gene Chr15:76200624-76221962 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022420
 protein coding gene Chr15:79824317-79846231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019949
 protein coding gene Chr15:70794320-70812108 (-)
CAST/EiJ MGP_CASTEiJ_G0021271
 protein coding gene Chr15:77003016-77022751 (-)
CBA/J MGP_CBAJ_G0021719
 protein coding gene Chr15:82361149-82387225 (-)
DBA/2J MGP_DBA2J_G0021844
 protein coding gene Chr15:73677565-73698897 (-)
FVB/NJ MGP_FVBNJ_G0021824
 protein coding gene Chr15:72735228-72756390 (-)
LP/J MGP_LPJ_G0021915
 protein coding gene Chr15:77044248-77063986 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021849
 protein coding gene Chr15:87691071-87711137 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022440
 protein coding gene Chr15:76425563-76444662 (-)
PWK/PhJ MGP_PWKPhJ_G0021012
 protein coding gene Chr15:73847170-73866680 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020852
 protein coding gene Chr15:76130299-76151783 (-)
WSB/EiJ MGP_WSBEiJ_G0021323
 protein coding gene Chr15:76525598-76547621 (-)



Homology
more
  • Human Ortholog
    ZNF251, zinc finger protein 251
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impairs glucose metabolism and adipocyte hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    32
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71591 NCBI Gene Model | MGI Sequence Detail 19305 C57BL/6J ±  kb
    transcript NM_001007568 RefSeq | MGI Sequence Detail 3514 C57BL/6  
    polypeptide NP_001007569 RefSeq | MGI Sequence Detail 632 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR036051 KRAB domain superfamily
      IPR001909 Krueppel-associated box
      IPR050169 Krueppel C2H2-type zinc-finger
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    • GlyGen
      Q6PCX8 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146174
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 2
      Phenotypes 29
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:334395 Kim E, et al., Zinc finger protein 251 deficiency impairs glucose metabolism by inducing adipocyte hypertrophy. Mol Cell Endocrinol. 2022 Dec 21;562:111838
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory