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Aox4 Gene Detail
Summary
  • Symbol
    Aox4
  • Name
    aldehyde oxidase 4
  • Synonyms
    2310003G12Rik, AOH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919122
    NCBI Gene: 71872
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:58249556-58307756 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 28.97 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1940 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919122
 protein coding gene Chr1:58249556-58307759 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016047
 protein coding gene Chr1:58052133-58117238 (+)
A/J MGP_AJ_G0016030
 protein coding gene Chr1:56035060-56094188 (+)
AKR/J MGP_AKRJ_G0015986
 protein coding gene Chr1:57541367-57602922 (+)
BALB/cJ MGP_BALBcJ_G0015985
 protein coding gene Chr1:56064422-56124154 (+)
C3H/HeJ MGP_C3HHeJ_G0015817
 protein coding gene Chr1:57815029-57878883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016438
 protein coding gene Chr1:60418070-60480232 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014160
 protein coding gene Chr1:51971489-52032186 (+)
CAST/EiJ MGP_CASTEiJ_G0015399
 protein coding gene Chr1:57065932-57124507 (+)
CBA/J MGP_CBAJ_G0015789
 protein coding gene Chr1:62172738-62246957 (+)
DBA/2J MGP_DBA2J_G0015890
 protein coding gene Chr1:55437168-55498191 (+)
FVB/NJ MGP_FVBNJ_G0015892
 protein coding gene Chr1:54772328-54830910 (+)
LP/J MGP_LPJ_G0015962
 protein coding gene Chr1:58943477-59015963 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015912
 protein coding gene Chr1:65186799-65247155 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016485
 protein coding gene Chr1:57534508-57594609 (+)
PWK/PhJ MGP_PWKPhJ_G0015185
 protein coding gene Chr1:54825476-54884183 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014966
 protein coding gene Chr1:57112880-57170976 (+)
WSB/EiJ MGP_WSBEiJ_G0015462
 protein coding gene Chr1:57201289-57263226 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a slight decrease in prenatal survival and epidermal thickening that is exacerbated by UV treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    2
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038242 Ensembl Gene Model | MGI Sequence Detail 58201 C57BL/6J ±  kb
    transcript ENSMUST00000040442 Ensembl | MGI Sequence Detail 4973 Not Applicable  
    polypeptide ENSMUSP00000048929 Ensembl | MGI Sequence Detail 1336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      1.17.3.-, 1.2.3.1
    • InterPro Domains
      IPR002888 [2Fe-2S]-binding
      IPR036884 [2Fe-2S]-binding domain superfamily
      IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
      IPR036010 2Fe-2S ferredoxin-like superfamily
      IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
      IPR014313 Aldehyde oxidase
      IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
      IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
      IPR008274 Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain
      IPR016208 Aldehyde oxidase/xanthine dehydrogenase-like
      IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
      IPR046867 Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain
      IPR012675 Beta-grasp domain superfamily
      IPR005107 CO dehydrogenase flavoprotein, C-terminal
      IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily
      IPR016166 FAD-binding domain, PCMH-type
      IPR036318 FAD-binding, type PCMH-like superfamily
      IPR016167 FAD-binding, type PCMH, subdomain 1
      IPR016169 FAD-binding, type PCMH, subdomain 2
      IPR002346 Molybdopterin dehydrogenase, FAD-binding
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264374 Terao M, et al., Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity. Sci Rep. 2016 Jul 26;6:30343
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory