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Usp42 Gene Detail
Summary
  • Symbol
    Usp42
  • Name
    ubiquitin specific peptidase 42
  • Synonyms
    2410140K03Rik, 3110031A07Rik, A630018G05Rik, D5Ertd591e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924050
    NCBI Gene: 76800
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143696080-143718035 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.50 cM, cytoband G2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924050
 protein coding gene Chr5:143696077-143741600 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030336
 protein coding gene Chr5:149071039-149093804 (-)
A/J MGP_AJ_G0030305
 protein coding gene Chr5:142661284-142684106 (-)
AKR/J MGP_AKRJ_G0030237
 protein coding gene Chr5:147126149-147148176 (-)
BALB/cJ MGP_BALBcJ_G0030322
 protein coding gene Chr5:143910459-143932256 (-)
C3H/HeJ MGP_C3HHeJ_G0030033
 protein coding gene Chr5:147950973-147974035 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030767
 protein coding gene Chr5:154507068-154529050 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027985
 protein coding gene Chr5:136430566-136452978 (-)
CAST/EiJ MGP_CASTEiJ_G0029438
 protein coding gene Chr5:147463403-147487956 (-)
CBA/J MGP_CBAJ_G0030003
 protein coding gene Chr5:160869863-160892154 (-)
DBA/2J MGP_DBA2J_G0030153
 protein coding gene Chr5:142433380-142455322 (-)
FVB/NJ MGP_FVBNJ_G0030108
 protein coding gene Chr5:141636843-141660972 (-)
LP/J MGP_LPJ_G0030239
 protein coding gene Chr5:149677285-149699219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030139
 protein coding gene Chr5:163248504-163273047 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030807
 protein coding gene Chr5:146990894-147015663 (-)
PWK/PhJ MGP_PWKPhJ_G0029153
 protein coding gene Chr5:141526073-141548456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028989
 protein coding gene Chr5:144745303-144768639 (-)
WSB/EiJ MGP_WSBEiJ_G0029511
 protein coding gene Chr5:147788257-147810230 (-)



Homology
more
  • Human Ortholog
    USP42, ubiquitin specific peptidase 42
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP42, ubiquitin specific peptidase 42
  • Links
    NCBI Gene ID: 84132
    neXtProt AC: NX_Q9H9J4
    UniProt: Q9H9J4

  • Chr Location
    7p22.1; chr7:6081241-6161564 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit fecundity and behavioral abnormalities, hyperactivity, increased T cell number, abnormal lens morphology, and cataracts. Males display oligozoospermia and testis degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    44
  • cDNA Data
    86
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051306 Ensembl Gene Model | MGI Sequence Detail 21956 C57BL/6J ±  kb
    transcript ENSMUST00000053287 Ensembl | MGI Sequence Detail 5151 Not Applicable  
    polypeptide ENSMUSP00000053955 Ensembl | MGI Sequence Detail 1324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 86
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261892, MGI:1920429, MGI:2444457
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory