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Rnase4 Gene Detail
Summary
  • Symbol
    Rnase4
  • Name
    ribonuclease, RNase A family 4
  • Synonyms
    C730049F20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926217
    NCBI Gene: 58809
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51328534-51343608 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.37 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    593 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926217
 protein coding gene Chr14:51328534-51343608 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021272
 protein coding gene Chr14:45054548-45073564 (+)
A/J MGP_AJ_G0021226
 protein coding gene Chr14:43704153-43719965 (+)
AKR/J MGP_AKRJ_G0021202
 protein coding gene Chr14:45353901-45368983 (+)
BALB/cJ MGP_BALBcJ_G0021229
 protein coding gene Chr14:43824801-43844937 (+)
C3H/HeJ MGP_C3HHeJ_G0021011
 protein coding gene Chr14:45175392-45190292 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021666
 protein coding gene Chr14:46906077-46922663 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019217
 protein coding gene Chr14:43037764-43052374 (+)
CAST/EiJ MGP_CASTEiJ_G0020535
 protein coding gene Chr14:42241074-42262388 (+)
CBA/J MGP_CBAJ_G0020978
 protein coding gene Chr14:48364052-48378968 (+)
DBA/2J MGP_DBA2J_G0021102
 protein coding gene Chr14:43598590-43613466 (+)
FVB/NJ MGP_FVBNJ_G0021082
 protein coding gene Chr14:43223067-43244229 (+)
LP/J MGP_LPJ_G0021170
 protein coding gene Chr14:45348179-45364389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021110
 protein coding gene Chr14:47857576-47879029 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021695
 protein coding gene Chr14:44838691-44853654 (+)
PWK/PhJ MGP_PWKPhJ_G0020285
 protein coding gene Chr14:40499254-40532663 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020110
 protein coding gene Chr14:41007490-41028629 (+)
WSB/EiJ MGP_WSBEiJ_G0020588
 protein coding gene Chr14:45036910-45053009 (+)



Homology
more
  • Human Ortholog
    RNASE4, ribonuclease A family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE4, ribonuclease A family member 4
  • Synonyms
    RAB1, RNS4
  • Links
    NCBI Gene ID: 6038
    neXtProt AC: NX_P34096
    UniProt: P34096

  • Chr Location
    14q11.2; chr14:20684560-20701216 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased susceptibility to induced colitis with altered intestinal microbiota.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    8
  • cDNA Data
    7
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58809 NCBI Gene Model | MGI Sequence Detail 15075 C57BL/6J ±  kb
    transcript NM_201239 RefSeq | MGI Sequence Detail 1837 C57BL/6  
    polypeptide Q9JJH1 UniProt | EBI | MGI Sequence Detail 148 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2442584
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:44252 Batten D, et al., Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family. Nucleic Acids Res. 1997 Nov 1;25(21):4235-9
    • Latest
      J:354138 Sun J, et al., Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis. Nat Commun. 2024 Jul 10;15(1):5778
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory