Trio MGI Mouse Gene Detail - MGI:1927230 - triple functional domain (PTPRF interacting)

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Trio Gene Detail

Symbol

Trio
Name

triple functional domain (PTPRF interacting)
Synonyms

6720464I07Rik, Solo

Feature Type

protein coding gene
IDs

MGI:1927230
NCBI Gene: 223435
Alliance

gene page
Transcription Start Sites

28 TSS

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Sequence Map

Chr15:27730737-28025934 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 10.40 cM
Mapping Data

3 experiments

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SNPs within 2kb

9079 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1927230	protein coding gene	Chr15:27730735-28025954 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021758	protein coding gene	Chr15:25803975-26102651 (-)
A/J	MGP_AJ_G0021719	protein coding gene	Chr15:24818939-25114253 (-)
AKR/J	MGP_AKRJ_G0021697	protein coding gene	Chr15:25396142-25692825 (-)
BALB/cJ	MGP_BALBcJ_G0021726	protein coding gene	Chr15:24789146-25087754 (-)
C3H/HeJ	MGP_C3HHeJ_G0021501	protein coding gene	Chr15:25451094-25750803 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022165	protein coding gene	Chr15:26856508-27154894 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019704	protein coding gene	Chr15:23126757-23413354 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0021470	protein coding gene	Chr15:27637903-27946207 (-)
DBA/2J	MGP_DBA2J_G0021594	protein coding gene	Chr15:24570981-24864305 (-)
FVB/NJ	MGP_FVBNJ_G0021572	protein coding gene	Chr15:24145255-24453330 (-)
LP/J	MGP_LPJ_G0021662	protein coding gene	Chr15:25670567-25987118 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021597	protein coding gene	Chr15:30395647-30700053 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022188	protein coding gene	Chr15:25618027-25917175 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0020598	protein coding gene	Chr15:25429345-25730711 (-)
WSB/EiJ	no annotation

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Human Ortholog

TRIO, trio Rho guanine nucleotide exchange factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIO, trio Rho guanine nucleotide exchange factor
Synonyms

ARHGEF23, MEBAS, MRD44, MRD63, tgat
Links

HGNC:12303

NCBI Gene ID: 7204

neXtProt AC: NX_O75962

UniProt: O75962
Chr Location

5p15.2; chr5:14143342-14532128 (+) GRCh38

MGI Vertebrate Homology

Trio stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRIO
Gene Tree

Trio

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Diseases

2 with human TRIO associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469
				autosomal dominant intellectual developmental disorder 44 IDs autosomal dominant intellectual developmental disorder 44 DOID:0070074 OMIM:617061

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

34 phenotypes from 3 alleles in 4 genetic backgrounds
6 images
30 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

5
Targeted

10
Genomic Mutations

2 involving Trio
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

134 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice die during late embryonic development or shortly after birth. They exhibit abnormal skeletal myogenesis and display aberrant organization within the hippocampus and olfactory bulb.

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All GO Annotations

45
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

835
Tissues

44
cDNA Data

14
Literature Summary

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TRIO

Xenbase trio

ZFIN triob

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All Sequences

82
RefSeq

22
UniProt

7
CCDS

CCDS49587.1

Ensembl

ENSMUSG00000022263 (Evidence)
NCBI Gene

223435

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000022263	Ensembl Gene Model \| MGI Sequence Detail	295198	C57BL/6J	± kb
	transcript	ENSMUST00000090247	Ensembl \| MGI Sequence Detail	11495	Not Applicable
	polypeptide	ENSMUSP00000087714	Ensembl \| MGI Sequence Detail	3103	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016668 triple functional domain protein

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR051129 Calcium/calmodulin-dependent serine/threonine kinase

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR047054 Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1

IPR028570 Kalirin/Triple functional domain protein, SH3 domain 1

IPR047053 Kalirin/Triple functional domain protein, SH3 domain 2

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR051336 Rho GTPase-activating Guanine Nucleotide Exchange Factors

IPR008271 Serine/threonine-protein kinase, active site

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR018159 Spectrin/alpha-actinin

IPR002017 Spectrin repeat
GlyGen

Q0KL02 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 19

cDNA 15

Primer pair 2

Other 2

Microarray probesets 6

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MGI:1924980, MGI:2145897

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Summaries

All 75

Developmental Gene Expression 12

Gene Ontology 11

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trio:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133909	Chr15:28026096-28026107 (-)	-168 bp
Tssr133908	Chr15:28026068-28026087 (-)	-144 bp
Tssr133907	Chr15:28026053-28026067 (-)	-126 bp
Tssr133906	Chr15:28026038-28026051 (-)	-111 bp
Tssr133905	Chr15:28026012-28026036 (-)	-90 bp
Tssr133904	Chr15:28025980-28026010 (-)	-61 bp
Tssr133903	Chr15:28025920-28025965 (-)	-9 bp
Tssr133902	Chr15:28024543-28024559 (-)	1,383 bp
Tssr133901	Chr15:28022273-28022276 (-)	3,659 bp
Tssr133898	Chr15:27968346-27968353 (-)	57,584 bp
Tssr133897	Chr15:27968314-27968326 (-)	57,614 bp
Tssr133896	Chr15:27968287-27968298 (-)	57,641 bp
Tssr133895	Chr15:27923778-27923825 (-)	102,132 bp
Tssr133894	Chr15:27876565-27876610 (-)	149,346 bp
Tssr133893	Chr15:27876541-27876564 (-)	149,381 bp
Tssr133892	Chr15:27856552-27856571 (-)	169,372 bp
Tssr133891	Chr15:27856513-27856549 (-)	169,403 bp
Tssr133890	Chr15:27840754-27840757 (-)	185,178 bp
Tssr133889	Chr15:27788693-27788704 (-)	237,235 bp
Tssr133888	Chr15:27788656-27788675 (-)	237,268 bp
Tssr133887	Chr15:27788626-27788644 (-)	237,299 bp
Tssr133886	Chr15:27788599-27788611 (-)	237,329 bp
Tssr133885	Chr15:27788398-27788507 (-)	237,481 bp
Tssr133884	Chr15:27788333-27788344 (-)	237,595 bp
Tssr133883	Chr15:27785462-27785474 (-)	240,466 bp
Tssr133882	Chr15:27772333-27772350 (-)	253,592 bp
Tssr133881	Chr15:27763138-27763145 (-)	262,792 bp
Tssr133880	Chr15:27755558-27755564 (-)	270,373 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24