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Dnajb2 Gene Detail
Summary
  • Symbol
    Dnajb2
  • Name
    DnaJ heat shock protein family (Hsp40) member B2
  • Synonyms
    2700059H22Rik, Dnajb10, mDj8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928739
    NCBI Gene: 56812
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75213050-75222336 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.64 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    309 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928739
 protein coding gene Chr1:75213039-75222336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016181
 protein coding gene Chr1:75800499-75809769 (+)
A/J MGP_AJ_G0016164
 protein coding gene Chr1:73159116-73168417 (+)
AKR/J MGP_AKRJ_G0016121
 protein coding gene Chr1:75188284-75197564 (+)
BALB/cJ MGP_BALBcJ_G0016119
 protein coding gene Chr1:73220046-73229137 (+)
C3H/HeJ MGP_C3HHeJ_G0015950
 protein coding gene Chr1:75521501-75531373 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016572
 protein coding gene Chr1:78749584-78758891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014293
 protein coding gene Chr1:68719556-68729474 (+)
CAST/EiJ MGP_CASTEiJ_G0015534
 protein coding gene Chr1:74862062-74873114 (+)
CBA/J MGP_CBAJ_G0015923
 protein coding gene Chr1:81309989-81319104 (+)
DBA/2J MGP_DBA2J_G0016024
 protein coding gene Chr1:72477339-72486428 (+)
FVB/NJ MGP_FVBNJ_G0016027
 protein coding gene Chr1:71676633-71687429 (+)
LP/J MGP_LPJ_G0016096
 protein coding gene Chr1:76924756-76934041 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016047
 protein coding gene Chr1:84667879-84677134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016619
 protein coding gene Chr1:75259271-75268556 (+)
PWK/PhJ MGP_PWKPhJ_G0015321
 protein coding gene Chr1:71948813-71958209 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015099
 protein coding gene Chr1:74621775-74630978 (+)
WSB/EiJ MGP_WSBEiJ_G0015596
 protein coding gene Chr1:75071169-75080444 (+)



Homology
more
  • Human Ortholog
    DNAJB2, DnaJ heat shock protein family (Hsp40) member B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJB2, DnaJ heat shock protein family (Hsp40) member B2
  • Synonyms
    CMT2T, DSMA5, HMNR5, HSJ-1, HSJ1, HSPF3
  • Links
    NCBI Gene ID: 3300
    neXtProt AC: NX_P25686
    UniProt: P25686

  • Chr Location
    2q35; chr2:219279342-219286898 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DNAJB2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    6
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Dnajb2
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    4
  • cDNA Data
    81
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026203 Ensembl Gene Model | MGI Sequence Detail 9287 C57BL/6J ±  kb
transcript ENSMUST00000188931 Ensembl | MGI Sequence Detail 3066 Not Applicable  
polypeptide ENSMUSP00000140566 Ensembl | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    cDNA 81

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923843
References
more
  • Summaries
    All 54
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory