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Tlr9 Gene Detail
Summary
  • Symbol
    Tlr9
  • Name
    toll-like receptor 9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932389
    NCBI Gene: 81897
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106099797-106104075 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932389
 protein coding gene Chr9:106099797-106104082 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035224
 protein coding gene Chr9:108007548-108011832 (+)
A/J MGP_AJ_G0035204
 protein coding gene Chr9:104117809-104122093 (+)
AKR/J MGP_AKRJ_G0035136
 protein coding gene Chr9:106707674-106711958 (+)
BALB/cJ MGP_BALBcJ_G0035197
 protein coding gene Chr9:103800380-103804664 (+)
C3H/HeJ MGP_C3HHeJ_G0034907
 protein coding gene Chr9:107116259-107120543 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035717
 protein coding gene Chr9:110969073-110973358 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032615
 protein coding gene Chr9:101612450-101616746 (+)
CAST/EiJ MGP_CASTEiJ_G0034219
 protein coding gene Chr9:107008450-107012735 (+)
CBA/J MGP_CBAJ_G0034876
 protein coding gene Chr9:114873646-114877931 (+)
DBA/2J MGP_DBA2J_G0035037
 protein coding gene Chr9:103577221-103581505 (+)
FVB/NJ MGP_FVBNJ_G0034985
 protein coding gene Chr9:102348887-102353144 (+)
LP/J MGP_LPJ_G0035113
 protein coding gene Chr9:108235511-108239795 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035024
 protein coding gene Chr9:116528226-116532510 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035739
 protein coding gene Chr9:106951385-106955669 (+)
PWK/PhJ MGP_PWKPhJ_G0033926
 protein coding gene Chr9:103870435-103874720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033761
 protein coding gene Chr9:107007858-107012144 (+)
WSB/EiJ MGP_WSBEiJ_G0034339
 protein coding gene Chr9:106847496-106851780 (+)



Homology
more
  • Human Ortholog
    TLR9, toll like receptor 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR9, toll like receptor 9
  • Synonyms
    CD289
  • Links
    NCBI Gene ID: 54106
    neXtProt AC: NX_Q9NR96
    UniProt: Q9NR96

  • Chr Location
    3p21.2; chr3:52221080-52225645 (-)  GRCh38
Human Diseases
more
  • Diseases
    15 with human TLR9 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 10 alleles in 13 genetic backgrounds
    27 phenotypes from multigenic genotypes
    540 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit impaired immune responses to CpG DNA and altered susceptibility to EAE and parasitic infection. ENU-induced mutants may exhibit altered susceptibility to viral infection or induced colitis and impaired immune response to unmethylated CpG oligonucleotides.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    19
  • cDNA Data
    7
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 81897 NCBI Gene Model | MGI Sequence Detail 4279 C57BL/6J ±  kb
    transcript NM_031178 RefSeq | MGI Sequence Detail 3471 Not Specified  
    polypeptide Q9EQU3 UniProt | EBI | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 769
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 28
      Phenotypes 540
    • Earliest
      J:66049 Hemmi H, et al., A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5
    • Latest
      J:354887 Chen J, et al., DNA of neutrophil extracellular traps promote NF-kappaB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease. Signal Transduct Target Ther. 2024 Jun 17;9(1):163
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory