About   Help   FAQ
Prlhr Gene Detail
Summary
  • Symbol
    Prlhr
  • Name
    prolactin releasing hormone receptor
  • Synonyms
    Gpr10, GR3, LOC226278, PrRPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135956
    NCBI Gene: 226278
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr19:60455170-60456742 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 56.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135956
 protein coding gene Chr19:60454079-60457907 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025292
 protein coding gene Chr19:61039046-61040611 (-)
A/J MGP_AJ_G0025268
 protein coding gene Chr19:58061503-58063068 (-)
AKR/J MGP_AKRJ_G0025237
 protein coding gene Chr19:59875726-59877291 (-)
BALB/cJ MGP_BALBcJ_G0025263
 protein coding gene Chr19:58135412-58136977 (-)
C3H/HeJ MGP_C3HHeJ_G0025023
 protein coding gene Chr19:60129600-60131165 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025706
 protein coding gene Chr19:62506644-62508215 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023118
 protein coding gene Chr19:56899387-56901026 (-)
CAST/EiJ MGP_CASTEiJ_G0024488
 protein coding gene Chr19:60217249-60218814 (-)
CBA/J MGP_CBAJ_G0025003
 protein coding gene Chr19:65550437-65552002 (-)
DBA/2J MGP_DBA2J_G0025135
 protein coding gene Chr19:57813595-57815160 (-)
FVB/NJ MGP_FVBNJ_G0025096
 protein coding gene Chr19:57520942-57522507 (-)
LP/J MGP_LPJ_G0025221
 protein coding gene Chr19:60877858-60879423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025129
 protein coding gene Chr19:64732485-64734050 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025764
 protein coding gene Chr19:60121286-60122851 (-)
PWK/PhJ MGP_PWKPhJ_G0024236
 protein coding gene Chr19:57802964-57804529 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024039
 protein coding gene Chr19:58768474-58770043 (-)
WSB/EiJ MGP_WSBEiJ_G0024558
 protein coding gene Chr19:60223890-60225455 (-)



Homology
more
  • Human Ortholog
    PRLHR, prolactin releasing hormone receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRLHR, prolactin releasing hormone receptor
  • Synonyms
    GPR10, GR3, PrRPR
  • Links
    NCBI Gene ID: 2834
    neXtProt AC: NX_P49683
    UniProt: P49683

  • Chr Location
    10q26.11; chr10:118589997-118595648 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRLHR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045052 Ensembl Gene Model | MGI Sequence Detail 1573 C57BL/6J ±  kb
    transcript ENSMUST00000051277 Ensembl | MGI Sequence Detail 1573 Not Applicable  
    polypeptide ENSMUSP00000063114 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685185
    References
    more
    • Summaries
      All 31
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:90533 Gu W, et al., The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. J Mol Neurosci. 2004;22(1-2):93-103
    • Latest
      J:339803 Talbot F, et al., A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Nat Commun. 2023 Mar 15;14(1):1450
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory