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Sfxn4 Gene Detail
Summary
  • Symbol
    Sfxn4
  • Name
    sideroflexin 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137680
    NCBI Gene: 94281
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:60825715-60849917 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 56.52 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    699 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137680
 protein coding gene Chr19:60824747-60850222 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025297
 protein coding gene Chr19:61447356-61473115 (-)
A/J MGP_AJ_G0025273
 protein coding gene Chr19:58442891-58467791 (-)
AKR/J MGP_AKRJ_G0025242
 protein coding gene Chr19:60267619-60296579 (-)
BALB/cJ MGP_BALBcJ_G0025268
 protein coding gene Chr19:58526616-58552562 (-)
C3H/HeJ MGP_C3HHeJ_G0025028
 protein coding gene Chr19:60512767-60539045 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025711
 protein coding gene Chr19:62900842-62928193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023123
 protein coding gene Chr19:57270122-57293551 (-)
CAST/EiJ MGP_CASTEiJ_G0024493
 protein coding gene Chr19:60615249-60641122 (-)
CBA/J MGP_CBAJ_G0025008
 protein coding gene Chr19:65963455-65992383 (-)
DBA/2J MGP_DBA2J_G0025140
 protein coding gene Chr19:58230389-58256446 (-)
FVB/NJ MGP_FVBNJ_G0025101
 protein coding gene Chr19:57894984-57920426 (-)
LP/J MGP_LPJ_G0025226
 protein coding gene Chr19:61276713-61304656 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025134
 protein coding gene Chr19:65153774-65184713 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025769
 protein coding gene Chr19:60509157-60534814 (-)
PWK/PhJ MGP_PWKPhJ_G0024241
 protein coding gene Chr19:58170532-58195261 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024044
 protein coding gene Chr19:59157744-59188485 (-)
WSB/EiJ MGP_WSBEiJ_G0024563
 protein coding gene Chr19:60618130-60643342 (-)



Homology
more
  • Human Ortholog
    SFXN4, sideroflexin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFXN4, sideroflexin 4
  • Synonyms
    BCRM1, COXPD18, SLC56A4
  • Links
    NCBI Gene ID: 119559
    neXtProt AC: NX_Q6P4A7
    UniProt: Q6P4A7

  • Chr Location
    10q26.11
Human Diseases
more
  • Diseases
    1 with human SFXN4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    15
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063698 Ensembl Gene Model | MGI Sequence Detail 24203 C57BL/6J ±  kb
transcript ENSMUST00000135808 Ensembl | MGI Sequence Detail 1309 Not Applicable  
polypeptide ENSMUSP00000118743 Ensembl | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:68377 Fleming MD, et al., A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 2001 Mar 15;15(6):652-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory