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Lrp1b Gene Detail
Summary
  • Symbol
    Lrp1b
  • Name
    low density lipoprotein-related protein 1B
  • Synonyms
    9630004P12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151136
    NCBI Gene: 94217
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:40485258-42543636 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.51 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59907 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151136
 protein coding gene Chr2:40485258-42543747 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025714
 protein coding gene Chr2:39426916-41574495 (-)
A/J MGP_AJ_G0025690
 protein coding gene Chr2:37847592-39894283 (-)
AKR/J MGP_AKRJ_G0025660
 protein coding gene Chr2:39035565-41139806 (-)
BALB/cJ MGP_BALBcJ_G0025685
 protein coding gene Chr2:37903150-39985544 (-)
C3H/HeJ MGP_C3HHeJ_G0025446
 protein coding gene Chr2:38968434-41094005 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026131
 protein coding gene Chr2:40581623-42849502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023537
 protein coding gene Chr2:36320624-38291407 (-)
CAST/EiJ MGP_CASTEiJ_G0024911
 protein coding gene Chr2:38907704-41083191 (-)
CBA/J MGP_CBAJ_G0025426
 protein coding gene Chr2:42113776-44501197 (-)
DBA/2J MGP_DBA2J_G0025557
 protein coding gene Chr2:37539647-39592961 (-)
FVB/NJ MGP_FVBNJ_G0025519
 protein coding gene Chr2:37409702-39433854 (-)
LP/J MGP_LPJ_G0025645
 protein coding gene Chr2:39308368-41427578 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025550
 protein coding gene Chr2:41731984-44638220 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026189
 protein coding gene Chr2:38904052-41034576 (-)
PWK/PhJ MGP_PWKPhJ_G0024652
 protein coding gene Chr2:37450152-39497892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024457
 protein coding gene Chr2:38995587-41116363 (-)
WSB/EiJ MGP_WSBEiJ_G0024978
 protein coding gene Chr2:39066971-41215360 (-)



Homology
more
  • Human Ortholog
    LRP1B, LDL receptor related protein 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRP1B, LDL receptor related protein 1B
  • Synonyms
    LRP-1B, LRP-DIT, LRPDIT
  • Links
    NCBI Gene ID: 53353
    neXtProt AC: NX_Q9NZR2
    UniProt: Q9NZR2

  • Chr Location
    2q22.1-q22.2; chr2:140231423-142131016 (-)  GRCh38
Human Diseases
more
  • Diseases
    11 with human LRP1B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    36
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049252 Ensembl Gene Model | MGI Sequence Detail 2058379 C57BL/6J ±  kb
    transcript ENSMUST00000052550 Ensembl | MGI Sequence Detail 16294 Not Applicable  
    polypeptide ENSMUSP00000054275 Ensembl | MGI Sequence Detail 4599 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000009920 low-density lipoprotein receptor-related protein 1B
      (term hierarchy)
    • InterPro Domains
      IPR026823 Complement Clr-like EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR051221 Low-density lipoprotein receptor-related
      IPR051830 Neurogenic locus notch homolog
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR032485 Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain
      IPR011042 Six-bladed beta-propeller, TolB-like
    • GlyGen
      Q9JI18 49 sites, 32 N-linked glycans (34 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2445076
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory