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Gene Expression Data
Assay Details
Assay
Reference: J:74909 Gerety SS, et al., Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development. 2002 Mar;129(6):1397-410
Assay type: Immunohistochemistry
MGI Accession ID: MGI:2176581
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 3A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 3A Expression is present in the endothelium of the vasculature.
Specimen 3B: embryonic day 9.5; Efnb2tm1And/Efnb2tm1And (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 3B Expression is present in the endothelium of the vasculature. The vascular system is disorganized and less intricately developed in mutants compared to wild type.
Specimen 3C: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: blood vessel Present 3C Expression is present in the endothelium of the vasculature. The vascular system is disorganized and less intricately developed in mutants compared to wild type.
Specimen 3D: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 3D Expression is present in the endothelium of the vasculature.
Specimen 3E: embryonic day 9.5; Efnb2tm2And/Efnb2+, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: blood vessel Present 3E Expression is present in the endothelium of the vasculature.
Specimen 3F: embryonic day 9.5; Efnb2tm1And/Efnb2+, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: blood vessel Present 3F Expression is present in the endothelium of the vasculature.
Specimen 4G: embryonic day 9.5; Efnb2tm1And/Efnb2+ (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present Regionally restricted 4G Expression in the yolk sac vasculature.
Specimen 4H: embryonic day 9.5; Efnb2tm1And/Efnb2tm1And (more )
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present Regionally restricted 4H There are defects in arterial and venous angiogeneis remodeling in the yolk sac of the mutants.
Specimen 4I: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: extraembryonic vascular system Present Regionally restricted 4I There are defects in arterial and venous angiogeneis remodeling in the yolk sac of the mutants.
Specimen 5M: embryonic day 9.5; Efnb2tm1And/Efnb2+ (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 5M Staining in the vasculature.
TS15: anterior cardinal vein Present 5M
Specimen 5N: embryonic day 9.5; Efnb2tm1And/Efnb2tm1And (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 5N Staining in the vasculature.
TS15: anterior cardinal vein Present 5N There is defective remodeling of the anterior cardinal vein in the mutants, resulting in a plexus of disorganized, small diameter vessels.
Specimen 5O: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: blood vessel Present 5O Staining in the vasculature.
TS15: anterior cardinal vein Present 5O There is defective remodeling of the anterior cardinal vein in the mutants, resulting in a plexus of disorganized, small diameter vessels.
Specimen 6M: embryonic day 9.5; Efnb2tm1And/Efnb2+ (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 6M Expression in endothelial cells in the head.
TS15: internal carotid artery Present 6M Expression in endothelial cells in the head.
Specimen 6N: embryonic day 9.5; Efnb2tm1And/Efnb2tm1And (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 6N There is arrested vascular remodeling in the heads of the mutants.
TS15: internal carotid artery Present 6N There is arrested vascular remodeling in the heads of the mutants.
Specimen 6O: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: blood vessel Present 6O There is arrested vascular remodeling in the heads of the mutants.
TS15: internal carotid artery Present 6O There is arrested vascular remodeling in the heads of the mutants.
Specimen 7M: embryonic day 9.5; Efnb2tm1And/Efnb2+ (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 7M Areas of expression include the intersomitic vessels in the trunk.
Specimen 7N: embryonic day 9.5; Efnb2tm1And/Efnb2tm1And (more )
Structure Level Pattern Image Note
TS15: blood vessel Present 7N There is an absence of intersomitic vessel remodeling in the mutant.
Specimen 7O: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: blood vessel Present 7O There is an absence of intersomitic vessel remodeling in the mutant.
Specimen 8G: embryonic day 9.5; Efnb2tm1And/Efnb2+ (more )
Structure Level Pattern Image Note
TS15: heart Present 8G
Specimen 8H: embryonic day 9.5; Efnb2tm1And/Efnb2tm1And (more )
Structure Level Pattern Image Note
TS15: heart Present 8H There is defective swelling and looping in the mutant heart.
Specimen 8I: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: heart Present 8I There is defective swelling and looping in the mutant heart.
Specimen 8J: embryonic day 9.5; Efnb2tm1And/Efnb2+ (more )
Structure Level Pattern Image Note
TS15: heart Present 8J
Specimen 8K: embryonic day 9.5; Efnb2tm1And/Efnb2tm1And (more )
Structure Level Pattern Image Note
TS15: heart Present 8K There is little or no mycardial trabeculation in the mutant compared to wild type.
Specimen 8L: embryonic day 9.5; Efnb2tm1And/Efnb2tm2And, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: heart Present 8L There is little or no mycardial trabeculation in the mutant compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
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