About   Help   FAQ
Stab2 Gene Detail
Summary
  • Symbol
    Stab2
  • Name
    stabilin 2
  • Synonyms
    FEEL-2, STAB-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178743
    NCBI Gene: 192188
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:86677062-86843889 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 43.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5035 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178743
 protein coding gene Chr10:86677058-86843902 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017616
 protein coding gene Chr10:87821574-87997647 (-)
A/J MGP_AJ_G0017595
 protein coding gene Chr10:84916398-85094539 (-)
AKR/J MGP_AKRJ_G0017553
 protein coding gene Chr10:87304373-87475376 (-)
BALB/cJ MGP_BALBcJ_G0017558
 protein coding gene Chr10:85179089-85352005 (-)
C3H/HeJ MGP_C3HHeJ_G0017381
 protein coding gene Chr10:87300192-87474265 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018015
 protein coding gene Chr10:90797939-90984877 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015697
 protein coding gene Chr10:80718107-80888063 (-)
CAST/EiJ MGP_CASTEiJ_G0016946
 protein coding gene Chr10:87196275-87375085 (-)
CBA/J MGP_CBAJ_G0017350
 protein coding gene Chr10:94566138-94759239 (-)
DBA/2J MGP_DBA2J_G0017456
 protein coding gene Chr10:84019994-84192113 (-)
FVB/NJ MGP_FVBNJ_G0017448
 protein coding gene Chr10:83291474-83463525 (-)
LP/J MGP_LPJ_G0017530
 protein coding gene Chr10:88517426-88710170 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017479
 protein coding gene Chr10:96132271-96314726 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018052
 protein coding gene Chr10:87148422-87319917 (-)
PWK/PhJ MGP_PWKPhJ_G0016727
 protein coding gene Chr10:84033926-84209563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016515
 protein coding gene Chr10:85875900-86043957 (-)
WSB/EiJ MGP_WSBEiJ_G0017005
 protein coding gene Chr10:87114741-87289379 (-)



Homology
more
  • Human Ortholog
    STAB2, stabilin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAB2, stabilin 2
  • Synonyms
    FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1
  • Links
    NCBI Gene ID: 55576
    neXtProt AC: NX_Q8WWQ8
    UniProt: Q8WWQ8

  • Chr Location
    12q23.3; chr12:103587273-103766719 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit no gross abnormaities. Mice homozygous for one null allele display elevated serum hyaluronic acid levels and decreased metastasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    42
  • cDNA Data
    18
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035459 Ensembl Gene Model | MGI Sequence Detail 166828 C57BL/6J ±  kb
    transcript ENSMUST00000035288 Ensembl | MGI Sequence Detail 8228 Not Applicable  
    polypeptide ENSMUSP00000048309 Ensembl | MGI Sequence Detail 2559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354240 Krzistetzko J, et al., Association of Differentially Altered Liver Fibrosis with Deposition of TGFBi in Stabilin-Deficient Mice. Int J Mol Sci. 2023 Jun 30;24(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory