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Cd207 Gene Detail
Summary
  • Symbol
    Cd207
  • Name
    CD207 antigen
  • Synonyms
    Langerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180021
    NCBI Gene: 246278
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83648197-83654839 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM, cytoband D1-D2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180021
 protein coding gene Chr6:83648189-83654839 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030936
 protein coding gene Chr6:84693826-84700491 (-)
A/J MGP_AJ_G0030905
 protein coding gene Chr6:81476730-81483399 (-)
AKR/J MGP_AKRJ_G0030833
 protein coding gene Chr6:83830631-83837273 (-)
BALB/cJ MGP_BALBcJ_G0030915
 protein coding gene Chr6:81496431-81503096 (-)
C3H/HeJ MGP_C3HHeJ_G0030795
 protein coding gene Chr6:100563256-100569898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031375
 protein coding gene Chr6:87033655-87040297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028561
 protein coding gene Chr6:79836626-79843167 (-)
CAST/EiJ MGP_CASTEiJ_G0030024
 protein coding gene Chr6:83851437-83857858 (-)
CBA/J MGP_CBAJ_G0030602
 protein coding gene Chr6:90457702-90464344 (-)
DBA/2J MGP_DBA2J_G0030755
 protein coding gene Chr6:80786714-80793356 (-)
FVB/NJ MGP_FVBNJ_G0030708
 protein coding gene Chr6:79999653-80006322 (-)
LP/J MGP_LPJ_G0030834
 protein coding gene Chr6:84700916-84707571 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030744
 protein coding gene Chr6:94734117-94740786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031399
 protein coding gene Chr6:83654958-83661399 (-)
PWK/PhJ MGP_PWKPhJ_G0029739
 protein coding gene Chr6:79696825-79703363 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029567
 protein coding gene Chr6:82479992-82486611 (-)
WSB/EiJ MGP_WSBEiJ_G0030105
 protein coding gene Chr6:84077338-84083980 (-)



Homology
more
  • Human Ortholog
    CD207, CD207 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD207, CD207 molecule
  • Synonyms
    CLEC4K
  • Links
    NCBI Gene ID: 50489
    neXtProt AC: NX_Q9UJ71
    UniProt: Q9UJ71

  • Chr Location
    2p13.3; chr2:70824130-70835816 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    3
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034783 Ensembl Gene Model | MGI Sequence Detail 6643 C57BL/6J ±  kb
    transcript ENSMUST00000037882 Ensembl | MGI Sequence Detail 1522 Not Applicable  
    polypeptide ENSMUSP00000040746 Ensembl | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 2
      cDNA 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 4
      Phenotypes 127
    • Earliest
      J:59970 Valladeau J, et al., Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81
    • Latest
      J:351553 Cros A, et al., Homeostatic activation of aryl hydrocarbon receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration. Elife. 2023 May 16;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory