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Gpr142 Gene Detail
Summary
  • Symbol
    Gpr142
  • Name
    G protein-coupled receptor 142
  • Feature Type
    protein coding gene
  • IDs
    MGI:2668437
    NCBI Gene: 217302
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:114689750-114697571 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    308 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2668437
 protein coding gene Chr11:114689750-114697571 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019361
 protein coding gene Chr11:118738871-118747996 (+)
A/J MGP_AJ_G0019330
 protein coding gene Chr11:113577002-113584814 (+)
AKR/J MGP_AKRJ_G0019298
 protein coding gene Chr11:116936370-116944178 (+)
BALB/cJ MGP_BALBcJ_G0019303
 protein coding gene Chr11:113996284-114004663 (+)
C3H/HeJ MGP_C3HHeJ_G0019112
 protein coding gene Chr11:117285593-117295294 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019754
 protein coding gene Chr11:122303817-122311638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017377
 protein coding gene Chr11:110643602-110651378 (+)
CAST/EiJ MGP_CASTEiJ_G0018666
 protein coding gene Chr11:118617126-118624948 (+)
CBA/J MGP_CBAJ_G0019082
 protein coding gene Chr11:127191728-127203179 (+)
DBA/2J MGP_DBA2J_G0019194
 protein coding gene Chr11:113019367-113026945 (+)
FVB/NJ MGP_FVBNJ_G0019185
 protein coding gene Chr11:112502401-112509575 (+)
LP/J MGP_LPJ_G0019264
 protein coding gene Chr11:119144285-119155399 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019216
 protein coding gene Chr11:126351612-126359485 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019791
 protein coding gene Chr11:117612490-117620897 (+)
PWK/PhJ MGP_PWKPhJ_G0018431
 protein coding gene Chr11:114255407-114263357 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018223
 protein coding gene Chr11:117417786-117425405 (+)
WSB/EiJ MGP_WSBEiJ_G0018718
 protein coding gene Chr11:117569890-117580259 (+)



Homology
more
  • Human Ortholog
    GPR142, G protein-coupled receptor 142
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR142, G protein-coupled receptor 142
  • Synonyms
    GPRg1b, PGR2
  • Links
    NCBI Gene ID: 350383
    neXtProt AC: NX_Q7Z601
    UniProt: Q7Z601

  • Chr Location
    17q25.1; chr17:74367458-74372600 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show alterations in gut and pancreatic islet hormone secretion and glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    35
  • cDNA Data
    2
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217302 NCBI Gene Model | MGI Sequence Detail 7822 C57BL/6J ±  kb
    transcript NM_001346772 RefSeq | MGI Sequence Detail 1116 C57BL/6  
    polypeptide Q7TQN9 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 2
      cDNA 2
      Primer pair 1
      Other 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:106981 Susens U, et al., Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. Neuropharmacology. 2006 Mar;50(4):512-20
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory