About   Help   FAQ
Lmtk2 Gene Detail
Summary
  • Symbol
    Lmtk2
  • Name
    lemur tyrosine kinase 2
  • Synonyms
    2900041G10Rik, A330101P12Rik, AATYK2, BREK, cprk, KPI-2, KPI2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036247
    NCBI Gene: 231876
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:144037254-144125022 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.85 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2267 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036247
 protein coding gene Chr5:144037179-144125026 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030345
 protein coding gene Chr5:149420630-149512021 (+)
A/J MGP_AJ_G0030314
 protein coding gene Chr5:143006489-143097500 (+)
AKR/J MGP_AKRJ_G0030246
 protein coding gene Chr5:147463189-147552569 (+)
BALB/cJ MGP_BALBcJ_G0030331
 protein coding gene Chr5:144238197-144342693 (+)
C3H/HeJ MGP_C3HHeJ_G0030042
 protein coding gene Chr5:148304258-148395859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030776
 protein coding gene Chr5:154893734-154986185 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027995
 protein coding gene Chr5:136794933-136885890 (+)
CAST/EiJ MGP_CASTEiJ_G0029447
 protein coding gene Chr5:147821486-147916838 (+)
CBA/J MGP_CBAJ_G0030012
 protein coding gene Chr5:161232231-161341616 (+)
DBA/2J MGP_DBA2J_G0030162
 protein coding gene Chr5:142754147-142847744 (+)
FVB/NJ MGP_FVBNJ_G0030117
 protein coding gene Chr5:141977266-142066281 (+)
LP/J MGP_LPJ_G0030248
 protein coding gene Chr5:150029565-150125316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030148
 protein coding gene Chr5:163624083-163716313 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030816
 protein coding gene Chr5:147349105-147441409 (+)
PWK/PhJ MGP_PWKPhJ_G0029162
 protein coding gene Chr5:141866557-141958292 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028998
 protein coding gene Chr5:145093238-145178594 (+)
WSB/EiJ MGP_WSBEiJ_G0029520
 protein coding gene Chr5:148157147-148249330 (+)



Homology
more
  • Human Ortholog
    LMTK2, lemur tyrosine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMTK2, lemur tyrosine kinase 2
  • Synonyms
    AATYK2, BREK, cprk, hBREK, KPI-2, KPI2, LMR2, PPP1R100
  • Links
    NCBI Gene ID: 22853
    neXtProt AC: NX_Q8IWU2
    UniProt: Q8IWU2

  • Chr Location
    7q21.3; chr7:98106862-98209638 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation in this gene display partial prenatal lethality, male infertility, and azoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    101
  • cDNA Data
    99
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038970 Ensembl Gene Model | MGI Sequence Detail 87769 C57BL/6J ±  kb
    transcript ENSMUST00000041804 Ensembl | MGI Sequence Detail 8114 Not Applicable  
    polypeptide ENSMUSP00000048238 Ensembl | MGI Sequence Detail 1471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 99
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1920140
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory