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Chgb Gene Detail
Summary
  • Symbol
    Chgb
  • Name
    chromogranin B
  • Synonyms
    Scg-1, secretogranin I
  • Feature Type
    protein coding gene
  • IDs
    MGI:88395
    NCBI Gene: 12653
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132623562-132636999 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.74 cM, cytoband F-G
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    473 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88395
 protein coding gene Chr2:132623198-132636999 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026545
 protein coding gene Chr2:136406852-136422834 (+)
A/J MGP_AJ_G0026509
 protein coding gene Chr2:130836495-130851274 (+)
AKR/J MGP_AKRJ_G0026483
 protein coding gene Chr2:134626572-134640332 (+)
BALB/cJ MGP_BALBcJ_G0026521
 protein coding gene Chr2:131246374-131260528 (+)
C3H/HeJ MGP_C3HHeJ_G0026264
 protein coding gene Chr2:135059915-135076030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026966
 protein coding gene Chr2:140552688-140570735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024343
 protein coding gene Chr2:125566786-125580147 (+)
CAST/EiJ MGP_CASTEiJ_G0025725
 protein coding gene Chr2:135404535-135420139 (+)
CBA/J MGP_CBAJ_G0026244
 protein coding gene Chr2:145834320-145850733 (+)
DBA/2J MGP_DBA2J_G0026378
 protein coding gene Chr2:130225008-130238883 (+)
FVB/NJ MGP_FVBNJ_G0026342
 protein coding gene Chr2:128858209-128871805 (+)
LP/J MGP_LPJ_G0026482
 protein coding gene Chr2:136636759-136650392 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026362
 protein coding gene Chr2:149550448-149566674 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027021
 protein coding gene Chr2:134586171-134602225 (+)
PWK/PhJ MGP_PWKPhJ_G0025461
 protein coding gene Chr2:129838161-129852808 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025263
 protein coding gene Chr2:133748774-133763686 (+)
WSB/EiJ MGP_WSBEiJ_G0025799
 protein coding gene Chr2:135510196-135524771 (+)



Homology
more
  • Human Ortholog
    CHGB, chromogranin B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHGB, chromogranin B
  • Synonyms
    SCG1
  • Links
    NCBI Gene ID: 1114
    neXtProt AC: NX_P05060
    UniProt: P05060

  • Chr Location
    20p12.3; chr20:5911510-5925353 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced catecholamine secretion from adrenal chromaffin cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    956
  • Tissues
    102
  • cDNA Data
    63
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12653 NCBI Gene Model | MGI Sequence Detail 13438 C57BL/6J ±  kb
    transcript NM_007694 RefSeq | MGI Sequence Detail 2376 ZRU/MplStud  
    polypeptide P16014 UniProt | EBI | MGI Sequence Detail 677 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 1
      cDNA 66
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14309, MGD-MRK-1970
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 32
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:324555 Shue YT, et al., A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. Nat Commun. 2022 May 16;13(1):2690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory