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Hoxb7 Gene Detail
Summary
  • Symbol
    Hoxb7
  • Name
    homeobox B7
  • Synonyms
    Hox-2.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96188
    NCBI Gene: 15415
  • Member of
    Hoxb cluster
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96177449-96180988 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.82 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96188
 protein coding gene Chr11:96176431-96180989 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019003
 protein coding gene Chr11:98598638-98601976 (+)
A/J MGP_AJ_G0018971
 protein coding gene Chr11:94571484-94574824 (+)
AKR/J MGP_AKRJ_G0018941
 protein coding gene Chr11:97497121-97500667 (+)
BALB/cJ MGP_BALBcJ_G0018944
 protein coding gene Chr11:95070987-95074498 (+)
C3H/HeJ MGP_C3HHeJ_G0018758
 protein coding gene Chr11:97629048-97632567 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019396
 protein coding gene Chr11:101680988-101684517 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017026
 protein coding gene Chr11:92057891-92061382 (+)
CAST/EiJ MGP_CASTEiJ_G0018311
 protein coding gene Chr11:98449913-98454194 (+)
CBA/J MGP_CBAJ_G0018729
 protein coding gene Chr11:105842673-105845995 (+)
DBA/2J MGP_DBA2J_G0018837
 protein coding gene Chr11:94138429-94141932 (+)
FVB/NJ MGP_FVBNJ_G0018826
 protein coding gene Chr11:93617609-93620924 (+)
LP/J MGP_LPJ_G0018907
 protein coding gene Chr11:99135955-99139450 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018853
 protein coding gene Chr11:105838593-105842078 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019436
 protein coding gene Chr11:97804661-97808360 (+)
PWK/PhJ MGP_PWKPhJ_G0018083
 protein coding gene Chr11:95089993-95093377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017872
 protein coding gene Chr11:97530894-97534150 (+)
WSB/EiJ MGP_WSBEiJ_G0018361
 protein coding gene Chr11:97689988-97693797 (+)



Homology
more
  • Human Ortholog
    HOXB7, homeobox B7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXB7, homeobox B7
  • Synonyms
    HHO.C1, HOX2, Hox-2.3, HOX2C
  • Links
    NCBI Gene ID: 3217
    neXtProt AC: NX_P09629
    UniProt: P09629

  • Chr Location
    17q21.32; chr17:48607232-48633572 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit first and second rib defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    989
  • Tissues
    194
  • cDNA Data
    20
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038721 Ensembl Gene Model | MGI Sequence Detail 3540 C57BL/6J ±  kb
    transcript ENSMUST00000049352 Ensembl | MGI Sequence Detail 1291 Not Applicable  
    polypeptide ENSMUSP00000040121 Ensembl | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 18
      cDNA 25
      Primer pair 8
      Other 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10831, MGD-MRK-10889, MGI:2144127
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 45
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
    • Latest
      J:348704 Vong KI, et al., Risk of meningomyelocele mediated by the common 22q11.2 deletion. Science. 2024 May 3;384(6695):584-590
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory