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Mylpf Gene Detail
Summary
  • Symbol
    Mylpf
  • Name
    myosin light chain, phosphorylatable, fast skeletal muscle
  • Synonyms
    2410014J02Rik, MLC-2, MYL11
  • Feature Type
    protein coding gene
  • IDs
    MGI:97273
    NCBI Gene: 17907
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126808071-126813459 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97273
 protein coding gene Chr7:126808062-126813470 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033025
 protein coding gene Chr7:131542521-131548565 (+)
A/J MGP_AJ_G0033008
 protein coding gene Chr7:128040553-128045950 (+)
AKR/J MGP_AKRJ_G0032940
 protein coding gene Chr7:131290538-131295921 (+)
BALB/cJ MGP_BALBcJ_G0033013
 protein coding gene Chr7:127702054-127707439 (+)
C3H/HeJ MGP_C3HHeJ_G0032723
 protein coding gene Chr7:131225999-131232262 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033519
 protein coding gene Chr7:136651137-136657899 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030491
 protein coding gene Chr7:129254117-129259518 (+)
CAST/EiJ MGP_CASTEiJ_G0032052
 protein coding gene Chr7:123022328-123027696 (+)
CBA/J MGP_CBAJ_G0032696
 protein coding gene Chr7:141249395-141257985 (+)
DBA/2J MGP_DBA2J_G0032848
 protein coding gene Chr7:126012016-126017451 (+)
FVB/NJ MGP_FVBNJ_G0032801
 protein coding gene Chr7:125865345-125870811 (+)
LP/J MGP_LPJ_G0032942
 protein coding gene Chr7:133006087-133012843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032833
 protein coding gene Chr7:142398314-142403691 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033538
 protein coding gene Chr7:130303131-130309792 (+)
PWK/PhJ MGP_PWKPhJ_G0031759
 protein coding gene Chr7:119020717-119026055 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031605
 protein coding gene Chr7:117141452-117149504 (+)
WSB/EiJ MGP_WSBEiJ_G0032164
 protein coding gene Chr7:131279377-131284759 (+)



Homology
more
  • Human Ortholog
    MYL11, myosin light chain 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYL11, myosin light chain 11
  • Synonyms
    DA1C, HUMMLC2B, MLC2B, MRLC2, MYLPF
  • Links
    NCBI Gene ID: 29895
    neXtProt AC: NX_Q96A32
    UniProt: Q96A32

  • Chr Location
    16p11.2; chr16:30370934-30377991 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYL11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene die immediately after birth and completely lack skeletal muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    44
  • cDNA Data
    210
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17907 NCBI Gene Model | MGI Sequence Detail 5389 C57BL/6J ±  kb
    transcript NM_016754 RefSeq | MGI Sequence Detail 755 C57BL/6  
    polypeptide P97457 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 215
      cDNA 211
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12771, MGI:1915203
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:6283 Katcoff D, et al., Construction of recombinant plasmids containing rat muscle actin and myosin light chain DNA sequences. Proc Natl Acad Sci U S A. 1980 Feb;77(2):960-4
    • Latest
      J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory