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Oas1b Pseudogene Detail
Summary
  • Symbol
    Oas1b
  • Name
    2'-5' oligoadenylate synthetase 1B
  • Synonyms
    Flavivirus resistance, Flv, L1, Mmu-L1, Oias-2, Oias2, Wnv
Location &
Maps
more
  • Sequence Map
    Chr5:120950700-120962228 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband F
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97430
 polymorphic pseudogene Chr5:120950700-120962228 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009946
 polymorphic pseudogene Chr5:124230644-124242178 (+)
A/J MGP_AJ_G0009931
 polymorphic pseudogene Chr5:119063066-119078947 (+)
AKR/J MGP_AKRJ_G0009914
 polymorphic pseudogene Chr5:122928374-122941391 (+)
BALB/cJ MGP_BALBcJ_G0009914
 polymorphic pseudogene Chr5:120479125-120490656 (+)
C3H/HeJ MGP_C3HHeJ_G0009847
 polymorphic pseudogene Chr5:123484313-123507596 (+)
C57BL/6NJ MGP_C57BL6NJ_G0010164
 polymorphic pseudogene Chr5:128885953-128911660 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0009665
 polymorphic pseudogene Chr5:122569920-122624466 (+)
CBA/J MGP_CBAJ_G0009821
 polymorphic pseudogene Chr5:133927843-133949805 (+)
DBA/2J MGP_DBA2J_G0009848
 polymorphic pseudogene Chr5:119167529-119179372 (+)
FVB/NJ MGP_FVBNJ_G0009867
 polymorphic pseudogene Chr5:118104727-118119040 (+)
LP/J MGP_LPJ_G0009943
 polymorphic pseudogene Chr5:124691136-124714316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009833
 polymorphic pseudogene Chr5:137866705-137878049 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0010135
 polymorphic pseudogene Chr5:122494530-122506060 (+)
PWK/PhJ MGP_PWKPhJ_G0009585
 polymorphic pseudogene Chr5:117934627-117945488 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0009768
 polymorphic pseudogene Chr5:123082558-123113793 (+)



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Synonyms
    E18/E16, IFI-4, IMD100, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112905856-112933219 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 4 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    2
  • Genomic Mutations
    3 involving Oas1b
  • Find Mice (IMSR)
    15 strains or lines available
Spontaneous mutations of this gene result in altered susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    20
  • Literature Summary
    1
Sequences &
Gene Models
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  • All Sequences
    46
  • RefSeq
    3
  • UniProt
    6
Representative SequencesLengthStrain/SpeciesFlank
genomic 23961 NCBI Gene Model | MGI Sequence Detail 11529 C57BL/6J ±  kb
transcript NR_003507 RefSeq | MGI Sequence Detail 1848 ZRU/MplStud  
polypeptide Q60856 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012102 2'-5'-oligoadenylate synthetase 1B
    (term hierarchy)
  • InterPro Domains
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site
    IPR043519 Nucleotidyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 27
    Genomic 5
    cDNA 21
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13024, MGD-MRK-13026, MGD-MRK-9840, MGI:2388353, MGI:95562
References
more
  • Summaries
    All 65
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:13005 Webster LT, INHERITANCE OF RESISTANCE OF MICE TO ENTERIC BACTERIAL AND NEUROTROPIC VIRUS INFECTIONS. J Exp Med. 1937 Jan 31;65(2):261-86
  • Latest
    J:346169 Jasperse BA, et al., Neuroinvasive Flavivirus Pathogenesis Is Restricted by Host Genetic Factors in Collaborative Cross Mice, Independently of Oas1b. J Virol. 2023 Jul 27;97(7):e0071523
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory