Il1rl1 MGI Mouse Gene Detail - MGI:98427 - interleukin 1 receptor-like 1

Symbol

Il1rl1
Name

interleukin 1 receptor-like 1
Synonyms

DER4, Fit-1, Ly84, St2, ST2, ST2L, St2-rs1, T1, T1 gene, T1/ST2

Feature Type

protein coding gene
IDs

MGI:98427
NCBI Gene: 17082
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr1:40468730-40504575 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 19.19 cM
Mapping Data

3 experiments

SNPs within 2kb

1111 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98427	protein coding gene	Chr1:40444105-40504575 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015967	protein coding gene	Chr1:39228681-39266455 (+)
A/J	MGP_AJ_G0015951	protein coding gene	Chr1:38121161-38154368 (+)
AKR/J	MGP_AKRJ_G0015906	protein coding gene	Chr1:38599798-38630891 (+)
BALB/cJ	MGP_BALBcJ_G0015905	protein coding gene	Chr1:37775382-37805172 (+)
C3H/HeJ	MGP_C3HHeJ_G0015738	protein coding gene	Chr1:38902619-38936443 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016358	protein coding gene	Chr1:40833047-40872838 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014080	protein coding gene	Chr1:35047356-35077864 (+)
CAST/EiJ	MGP_CASTEiJ_G0015319	protein coding gene	Chr1:38799024-38828405 (+)
CBA/J	MGP_CBAJ_G0015710	protein coding gene	Chr1:42045058-42079833 (+)
DBA/2J	MGP_DBA2J_G0015811	protein coding gene	Chr1:37395048-37428721 (+)
FVB/NJ	MGP_FVBNJ_G0015813	protein coding gene	Chr1:36946210-36977303 (+)
LP/J	MGP_LPJ_G0015881	protein coding gene	Chr1:39559613-39595938 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015833	protein coding gene	Chr1:44054111-44090718 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016405	protein coding gene	Chr1:38756824-38792147 (+)
PWK/PhJ	MGP_PWKPhJ_G0015102	protein coding gene	Chr1:37213401-37243587 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014884	protein coding gene	Chr1:38722049-38757258 (+)
WSB/EiJ	MGP_WSBEiJ_G0015381	protein coding gene	Chr1:38722801-38762156 (+)

Human Ortholog

IL1RL1, interleukin 1 receptor like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL1RL1, interleukin 1 receptor like 1
Synonyms

DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
Links

HGNC:5998

NCBI Gene ID: 9173

neXtProt AC: NX_Q01638

UniProt: Q01638
Chr Location

2q12.1; chr2:102311502-102352356 (+) GRCh38

MGI Vertebrate Homology

Il1rl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL1RL1
Gene Tree

Il1rl1

Diseases

2 with human IL1RL1 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 3 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
233 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

12
Targeted

9
Transgenic

5
Genomic Mutations

1 involving Il1rl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display an abnormal Th2 type inflammatory response.

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All GO Annotations

41
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

53
cDNA Data

57
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN il1rl1

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All Sequences

61
RefSeq

14
UniProt

4
CCDS

CCDS35548.1, CCDS56626.1

Ensembl

ENSMUSG00000026069 (Evidence)
NCBI Gene

17082

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026069	Ensembl Gene Model \| MGI Sequence Detail	35846	C57BL/6J	± kb
transcript	ENSMUST00000097772	Ensembl \| MGI Sequence Detail	5302	Not Applicable
polypeptide	ENSMUSP00000095379	Ensembl \| MGI Sequence Detail	567	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008994 interleukin-1 receptor-like 1

(term hierarchy)
PDB

5VI4
EC

3.2.2.6
InterPro Domains

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR015621 Interleukin-1 receptor family

IPR004074 Interleukin-1 receptor type I/II

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
GlyGen

P14719 9 sites

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All nucleic 63

Genomic 3

cDNA 57

Primer pair 3

Microarray probesets 5

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MGD-MRK-14615, MGD-MRK-16618, MGI:99831

Summaries

All 320

Developmental Gene Expression 3

Gene Ontology 23

Phenotypes 233
Earliest

J:9936 Klemenz R, et al., Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5708-12
Latest

J:354671 Donahue KL, et al., Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth. Cancer Discov. 2024 Oct 4;14(10):1964-1989

TSS for Il1rl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6443	Chr1:40467449-40467480 (+)	-1,265 bp
Tssr6444	Chr1:40468296-40468337 (+)	-413 bp
Tssr6445	Chr1:40468356-40468369 (+)	-367 bp
Tssr6446	Chr1:40468723-40468746 (+)	5 bp
Tssr6447	Chr1:40469342-40469351 (+)	617 bp
Tssr6448	Chr1:40470203-40470217 (+)	1,480 bp
Tssr6449	Chr1:40470575-40470589 (+)	1,852 bp
Tssr6450	Chr1:40473057-40473065 (+)	4,331 bp
Tssr6451	Chr1:40473688-40473692 (+)	4,960 bp
Tssr6452	Chr1:40473958-40473979 (+)	5,239 bp
Tssr6453	Chr1:40476436-40476452 (+)	7,714 bp
Tssr6454	Chr1:40478802-40478809 (+)	10,076 bp
Tssr6455	Chr1:40478927-40478948 (+)	10,208 bp
Tssr6456	Chr1:40480445-40480456 (+)	11,721 bp
Tssr6457	Chr1:40480476-40480492 (+)	11,754 bp
Tssr6458	Chr1:40481747-40481766 (+)	13,027 bp
Tssr6459	Chr1:40484034-40484043 (+)	15,309 bp
Tssr6460	Chr1:40484066-40484081 (+)	15,344 bp
Tssr6461	Chr1:40487830-40487840 (+)	19,105 bp
Tssr6462	Chr1:40501391-40501409 (+)	32,670 bp
Tssr6463	Chr1:40501460-40501493 (+)	32,747 bp
Tssr6464	Chr1:40501500-40501518 (+)	32,779 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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