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Wnt6 Gene Detail
Summary
  • Symbol
    Wnt6
  • Name
    wingless-type MMTV integration site family, member 6
  • Synonyms
    Wnt-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:98960
    NCBI Gene: 22420
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74811051-74824481 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98960
 protein coding gene Chr1:74793499-74824481 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016162
 protein coding gene Chr1:75382786-75395998 (+)
A/J MGP_AJ_G0016145
 protein coding gene Chr1:72757371-72770761 (+)
AKR/J MGP_AKRJ_G0016102
 protein coding gene Chr1:74763145-74776657 (+)
BALB/cJ MGP_BALBcJ_G0016100
 protein coding gene Chr1:72812843-72826255 (+)
C3H/HeJ MGP_C3HHeJ_G0015931
 protein coding gene Chr1:75108339-75121573 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016553
 protein coding gene Chr1:78317581-78333912 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014274
 protein coding gene Chr1:68321187-68335719 (+)
CAST/EiJ MGP_CASTEiJ_G0015515
 protein coding gene Chr1:74430199-74445021 (+)
CBA/J MGP_CBAJ_G0015904
 protein coding gene Chr1:80869549-80883019 (+)
DBA/2J MGP_DBA2J_G0016005
 protein coding gene Chr1:72074317-72087725 (+)
FVB/NJ MGP_FVBNJ_G0016008
 protein coding gene Chr1:71267981-71281288 (+)
LP/J MGP_LPJ_G0016077
 protein coding gene Chr1:76498723-76512115 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016028
 protein coding gene Chr1:84249898-84264488 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016600
 protein coding gene Chr1:74838885-74852283 (+)
PWK/PhJ MGP_PWKPhJ_G0015302
 protein coding gene Chr1:71534860-71548365 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015080
 protein coding gene Chr1:74205828-74220608 (+)
WSB/EiJ MGP_WSBEiJ_G0015577
 protein coding gene Chr1:74649319-74662709 (+)



Homology
more
  • Human Ortholog
    WNT6, Wnt family member 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT6, Wnt family member 6
  • Links
    NCBI Gene ID: 7475
    neXtProt AC: NX_Q9Y6F9
    UniProt: Q9Y6F9

  • Chr Location
    2q35; chr2:218859805-218874233 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1288
  • Tissues
    429
  • cDNA Data
    27
  • Literature Summary
    114
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033227 Ensembl Gene Model | MGI Sequence Detail 13431 C57BL/6J ±  kb
    transcript ENSMUST00000006716 Ensembl | MGI Sequence Detail 2071 Not Applicable  
    polypeptide ENSMUSP00000006716 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 28
      Primer pair 15
      Other 12

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15445, MGD-MRK-15455, MGI:2138090
    References
    more
    • Summaries
      All 175
      Developmental Gene Expression 114
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353381 Kostic L, et al., Lgr5 marks stem/progenitor cells contributing to epithelial and muscle development in the mouse esophagus. Nat Commun. 2024 Aug 21;15(1):7145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory