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Wnt7a Gene Detail
Summary
  • Symbol
    Wnt7a
  • Name
    wingless-type MMTV integration site family, member 7A
  • Synonyms
    tw, Wnt-7a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98961
    NCBI Gene: 22421
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:91340963-91388335 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 40.45 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1085 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98961
 protein coding gene Chr6:91340963-91388345 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031045
 protein coding gene Chr6:92955419-93003194 (-)
A/J MGP_AJ_G0031013
 protein coding gene Chr6:89416901-89463723 (-)
AKR/J MGP_AKRJ_G0030945
 protein coding gene Chr6:91895445-91946304 (-)
BALB/cJ MGP_BALBcJ_G0031025
 protein coding gene Chr6:89356854-89404142 (-)
C3H/HeJ MGP_C3HHeJ_G0030683
 protein coding gene Chr6:92495976-92544887 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031484
 protein coding gene Chr6:95376696-95430484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028652
 protein coding gene Chr6:87397874-87444175 (-)
CAST/EiJ MGP_CASTEiJ_G0030132
 protein coding gene Chr6:92016757-92066114 (-)
CBA/J MGP_CBAJ_G0030711
 protein coding gene Chr6:98907383-98961110 (-)
DBA/2J MGP_DBA2J_G0030864
 protein coding gene Chr6:88597684-88647057 (-)
FVB/NJ MGP_FVBNJ_G0030818
 protein coding gene Chr6:87807979-87855773 (-)
LP/J MGP_LPJ_G0030944
 protein coding gene Chr6:92911989-92960138 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030852
 protein coding gene Chr6:102980838-103028740 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031511
 protein coding gene Chr6:91739291-91787420 (-)
PWK/PhJ MGP_PWKPhJ_G0029848
 protein coding gene Chr6:87548823-87596930 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029677
 protein coding gene Chr6:90646566-90696316 (-)
WSB/EiJ MGP_WSBEiJ_G0030216
 protein coding gene Chr6:92203689-92252822 (-)



Homology
more
  • Human Ortholog
    WNT7A, Wnt family member 7A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT7A, Wnt family member 7A
  • Synonyms
    Wnt-7a
  • Links
    NCBI Gene ID: 7476
    neXtProt AC: NX_O00755
    UniProt: O00755

  • Chr Location
    3p25.1; chr3:13816258-13880071 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wnt7a mouse models; 2 with human WNT7A associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 8 alleles in 9 genetic backgrounds
    20 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have skeletal abnormalities including absence of digits, especially of the forelimb, and sometimes absence of the ulna. Occasionally, there is an extra set of ribs. Both sexes are sterile due to abnormalities of the Mullerian duct.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    127
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1825
  • Tissues
    616
  • cDNA Data
    26
  • Literature Summary
    182
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22421 NCBI Gene Model | MGI Sequence Detail 47373 C57BL/6J ±  kb
    transcript NM_009527 RefSeq | MGI Sequence Detail 3179 ZRU/MplStud  
    polypeptide P24383 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      Genomic 1
      cDNA 29
      Primer pair 24
      Other 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13698, MGD-MRK-15446, MGD-MRK-15456, MGD-MRK-35364, MGI:2141500, MGI:97825
    References
    more
    • Summaries
      All 287
      Developmental Gene Expression 182
      Diseases 2
      Gene Ontology 27
      Phenotypes 55
    • Earliest
      J:112 Searle AG, The genetics and morphology of two 'luxoid' mutants in the house mouse. Genet Res. 1964;5(2):171-197
    • Latest
      J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory