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Etv2 Gene Detail
Summary
  • Symbol
    Etv2
  • Name
    ets variant 2
  • Synonyms
    Etsrp71
  • Feature Type
    protein coding gene
  • IDs
    MGI:99253
    NCBI Gene: 14008
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30333041-30335277 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 18.92 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99253
 protein coding gene Chr7:30333041-30335934 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032035
 protein coding gene Chr7:29646157-29648401 (-)
A/J MGP_AJ_G0032012
 protein coding gene Chr7:28839632-28841911 (-)
AKR/J MGP_AKRJ_G0031945
 protein coding gene Chr7:29572122-29574387 (-)
BALB/cJ MGP_BALBcJ_G0032019
 protein coding gene Chr7:29029087-29031340 (-)
C3H/HeJ MGP_C3HHeJ_G0031738
 protein coding gene Chr7:30035288-30037524 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032485
 protein coding gene Chr7:30607577-30609811 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029535
 protein coding gene Chr7:29867931-29870183 (-)
CAST/EiJ MGP_CASTEiJ_G0031072
 protein coding gene Chr7:23289771-23292017 (-)
CBA/J MGP_CBAJ_G0031704
 protein coding gene Chr7:32064004-32066240 (-)
DBA/2J MGP_DBA2J_G0031856
 protein coding gene Chr7:28568555-28570824 (-)
FVB/NJ MGP_FVBNJ_G0031813
 protein coding gene Chr7:28698953-28701187 (-)
LP/J MGP_LPJ_G0031937
 protein coding gene Chr7:29950102-29952359 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031849
 protein coding gene Chr7:31301059-31303322 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032513
 protein coding gene Chr7:29084863-29087142 (-)
PWK/PhJ MGP_PWKPhJ_G0030796
 protein coding gene Chr7:23608379-23610671 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030631
 protein coding gene Chr7:20095992-20098256 (-)
WSB/EiJ MGP_WSBEiJ_G0031182
 protein coding gene Chr7:29472523-29474759 (-)



Homology
more
  • Human Ortholog
    ETV2, ETS variant transcription factor 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ETV2, ETS variant transcription factor 2
  • Synonyms
    ER71, ETSRP71
  • Links
    NCBI Gene ID: 2116
    neXtProt AC: NX_O00321
    UniProt: O00321

  • Chr Location
    19q13.12; chr19:35641745-35644871 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ETV2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 6 alleles in 11 genetic backgrounds
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles die during organogenesis and lack blood vessels. In addition, mice homozygous for one allele lack endocardial cells, while mice homozygous for another allele lack blood cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    148
  • cDNA Data
    7
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006311 Ensembl Gene Model | MGI Sequence Detail 2237 C57BL/6J ±  kb
    transcript ENSMUST00000108147 Ensembl | MGI Sequence Detail 1048 Not Applicable  
    polypeptide ENSMUSP00000103782 Ensembl | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 7
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16011
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 28
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:19172 Brown TA, et al., Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 1992 Dec;6(12B):2502-12
    • Latest
      J:326952 Koyano-Nakagawa N, et al., Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud. Nat Commun. 2022 Jul 21;13(1):4221
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory