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Nrep Gene Detail
Summary
  • Symbol
    Nrep
  • Name
    neuronal regeneration related protein
  • Synonyms
    D0H4S114, P311, PTZ17, Sez17, SEZ17
  • Feature Type
    protein coding gene
  • IDs
    MGI:99444
    NCBI Gene: 27528
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:33570072-33597082 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    779 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99444
 protein coding gene Chr18:33570072-33597444 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024233
 protein coding gene Chr18:31601681-31628948 (-)
A/J MGP_AJ_G0024199
 protein coding gene Chr18:30535616-30562706 (-)
AKR/J MGP_AKRJ_G0024168
 protein coding gene Chr18:31366616-31394993 (-)
BALB/cJ MGP_BALBcJ_G0024199
 protein coding gene Chr18:30603724-30630969 (-)
C3H/HeJ MGP_C3HHeJ_G0023967
 protein coding gene Chr18:31430914-31457971 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024641
 protein coding gene Chr18:32777329-32804345 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022082
 protein coding gene Chr18:30713216-30740273 (-)
CAST/EiJ MGP_CASTEiJ_G0023442
 protein coding gene Chr18:31313369-31341111 (-)
CBA/J MGP_CBAJ_G0023935
 protein coding gene Chr18:33710918-33737781 (-)
DBA/2J MGP_DBA2J_G0024067
 protein coding gene Chr18:30212359-30239423 (-)
FVB/NJ MGP_FVBNJ_G0024033
 protein coding gene Chr18:29902911-29929911 (-)
LP/J MGP_LPJ_G0024148
 protein coding gene Chr18:31664395-31691459 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024061
 protein coding gene Chr18:35038818-35065653 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024689
 protein coding gene Chr18:31227529-31254691 (-)
PWK/PhJ MGP_PWKPhJ_G0023185
 protein coding gene Chr18:30371903-30399663 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022994
 protein coding gene Chr18:31488721-31515832 (-)
WSB/EiJ MGP_WSBEiJ_G0023505
 protein coding gene Chr18:31142751-31169936 (-)



Homology
more
  • Human Ortholog
    NREP, neuronal regeneration related protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NREP, neuronal regeneration related protein
  • Synonyms
    C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17
  • Links
    NCBI Gene ID: 9315
    neXtProt AC: NX_Q16612
    UniProt: Q16612

  • Chr Location
    5q22.1; chr5:111662621-111997464 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired pole-walking, olfactory discrimination, social transmission of food preference, spatial learning, and contextual conditioning behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    48
  • cDNA Data
    445
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042834 Ensembl Gene Model | MGI Sequence Detail 27011 C57BL/6J ±  kb
transcript ENSMUST00000168890 Ensembl | MGI Sequence Detail 2185 Not Applicable  
polypeptide ENSMUSP00000130297 Ensembl | MGI Sequence Detail 68 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 447
    cDNA 446
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16210, MGI:2147210
References
more
  • Summaries
    All 59
    Developmental Gene Expression 12
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:16366 Studler JM, et al., An Abundant Messenger RNA of the Embryonic Brain Persists at a High Level in Cerebellum, Hippocampus and Olfactory Bulb During Adulthood. Eur J Neurosci. 1993 Jun 1;5(6):614-623
  • Latest
    J:331810 Chen C, et al., P311 Promotes IL-4 ReceptorMediated M2 Polarization of Macrophages to Enhance Angiogenesis for Efficient Skin Wound Healing. J Invest Dermatol. 2022 Oct 26;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory