Cryge^nz
Radiation induced Allele Detail

Summary

• Symbol: Cryge^nz
• Name: crystallin, gamma E; dominant cataract 2, nuclear and zonular opacity
• MGI ID: MGI:1855995
• Synonyms: Cat2^nz, Cryge^Cat2-nz, Nzc
• Gene: Cryge Location: Chr1:65087713-65090308 bp, - strand Genetic Position: Chr1, 32.8 cM
• Alliance: Cryge^nz page

Mutation origin

• Strain of Origin: (101 x C3H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: A deletion of a T at position 89 in the encoded mRNA leads to a change in the open reading frame. The mutated sequence encodes a novel peptide of 125 amino acids, as detected in Western blotting of lens extracts derived from mutant mice. (J:66541)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cryge Mutation: 25 strains or lines available

Notes

Arose in descendants of irradiated mice. This mutation causes less severe defects than other Cat2 alleles.

Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous and homozygous mice (J:6686, J:9528)

References

• Original: J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
• All: 4 reference(s)