Fasl^gld
Spontaneous Allele Detail

Summary

• Symbol: Fasl^gld
• Name: Fas ligand; generalized lymphoproliferative disease
• MGI ID: MGI:1856384
• Synonyms: CD95-, FasL-, gld, Tnfsf6^gld
• Gene: Fasl Location: Chr1:161608260-161616064 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Fasl^gld page

control and Fasl^gld/Fasl^gld

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 (p.F273L) in the extracellular region of the encoded protein. (J:17445)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fasl^gld

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Fasl Mutation: 37 strains or lines available

References

• Original: J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
• All: 366 reference(s)