Tmc1^dn
Spontaneous Allele Detail

Summary

• Symbol: Tmc1^dn
• Name: transmembrane channel-like gene family 1; deafness
• MGI ID: MGI:1856845
• Synonyms: dn
• Gene: Tmc1 Location: Chr19:20760822-20931566 bp, - strand Genetic Position: Chr19, 13.98 cM, cytoband B
• Alliance: Tmc1^dn page

Mutation origin

• Strain of Origin: STOCK Grhl3^ct/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The mutation is a 1656 bp deletion including exon 14 and flanking intronic sequences. RT-PCR analysis confirmed that an mRNA was made that spliced exon 13 sequences in frame to exon 15 sequences. (J:75142)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tmc1 Mutation: 59 strains or lines available

References

• Original: J:236 Deol MS, et al., A new gene for deafness in the mouse. Heredity. 1958;12(4):463-6
• All: 31 reference(s)