B2m^tm1Unc
Targeted Allele Detail

Summary

• Symbol: B2m^tm1Unc
• Name: beta-2 microglobulin; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857133
• Synonyms: b2m^null, beta2M-, beta2m⁰, beta2-m-KO, beta2MKO, beta2m^null, beta2m^o, beta2m^tm1Unc, I⁰, MHC-I^-
• Gene: B2m Location: Chr2:121978168-121983563 bp, + strand Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
• Alliance: B2m^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65612
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Insertion of a neomycin-resistance gene into the second exon. (J:65612)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying B2m^tm1Unc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 38 strains available Cell Lines: 0 lines available
• Carrying any B2m Mutation: 122 strains or lines available

References

• Original: J:65612 Koller BH, et al., Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8932-5
• All: 559 reference(s)