Cd8a^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Cd8a^tm1Mak
• Name: CD8 subunit alpha; targeted mutation 1, Tak Mak
• MGI ID: MGI:1857149
• Synonyms: CD8-, CD8alpha-, CD8alpha^-, Cd8atm1Mak, CD8 KO, CD8-KO, CD8KO, Lyt-2-
• Gene: Cd8a Location: Chr6:71350411-71356155 bp, + strand Genetic Position: Chr6, 32.14 cM, cytoband C
• Alliance: Cd8a^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68956
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 1. Flow cytometry analysis on thymus and lymph node cells derived from homozygous mice confirmed that no detectable encoded protein was expressed on the cell surface. (J:68956, J:82297)

Tumor Data

List all tumor models in MMHCdb carrying Cd8a^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Cd8a Mutation: 39 strains or lines available

References

• Original: J:68956 Fung-Leung WP, et al., CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell. 1991 May 3;65(3):443-9
• All: 332 reference(s)