Il7r^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Il7r^tm1Imx
• Name: interleukin 7 receptor; targeted mutation 1, Immunex
• MGI ID: MGI:1857198
• Synonyms: CD127^-, IL-7R-, IL7R^-, IL-7Ralpha-
• Gene: Il7r Location: Chr15:9505874-9530262 bp, - strand Genetic Position: Chr15, 4.16 cM
• Alliance: Il7r^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21135
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 3 of the gene. (J:21135)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Il7r Mutation: 31 strains or lines available

References

• Original: J:21135 Peschon JJ, et al., Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med. 1994 Nov 1;180(5):1955-60
• All: 145 reference(s)