Tnfrsf1b^tm1Mwm
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1b^tm1Mwm
• Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1, Mark Moore
• MGI ID: MGI:1857262
• Synonyms: p75-, p75TNFR2-, TNF-R2^-, TNFR2⁰, Tnfr2^tm1Mwm, TNFR II -, TNFRp75^-
• Gene: Tnfrsf1b Location: Chr4:144940033-144973440 bp, - strand Genetic Position: Chr4, 78.17 cM
• Alliance: Tnfrsf1b^tm1Mwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21815
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2, which codes for the signal peptide region, was disrupted by the insertion of a neomycin cassette. To confirm that the gene was correctly targeted, mice were challenged with lipopolysaccharide (LPS) which results in shedding of the Tnfrsf1b extracellular domian in wild-type mice. No soluble Tnfrsf1b was detected in the serum of homozygous mutant animals. (J:21815)

Disease models

Expression

In Mice Carrying this Mutation:	104036 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1b Mutation: 41 strains or lines available

References

• Original: J:21815 Erickson SL, et al., Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature. 1994 Dec 8;372(6506):560-3
• All: 194 reference(s)