About   Help   FAQ
Jak3tm1Ljb
Targeted Allele Detail
Summary
Symbol: Jak3tm1Ljb
Name: Janus kinase 3; targeted mutation 1, Leslie J Berg
MGI ID: MGI:1857276
Synonyms: Jak-3-, Jak3-
Gene: Jak3  Location: Chr8:72129027-72143221 bp, + strand  Genetic Position: Chr8, 34.43 cM
Alliance: Jak3tm1Ljb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29722
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 0.6 kb fragment of the gene, which contains sequences encoding subdomains I to IV of the kinase domain. Protein immunoblots of lysates from bone marrow, spleen, and thymus showed no targeted protein. (J:29722)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jak3 Mutation:  84 strains or lines available
References
Original:  J:29722 Thomis DC, et al., Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3;270(5237):794-7
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory