Cd4^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Cd4^tm1Litt
• Name: CD4 antigen; targeted mutation 1, Dan R Littman
• MGI ID: MGI:1857281
• Synonyms: CD4-, Cd4^tm1Drl
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50435
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 5. No cell surface expression of the encoded protein was detected in T cells and thymocytes derived from homozygous mice (data not shown). (J:50435)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 85 strains or lines available

References

• Original: J:50435 Killeen N, et al., Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 1993 Apr;12(4):1547-53
• All: 59 reference(s)