Ifngr1^tm1Agt
Targeted Allele Detail

Summary

• Symbol: Ifngr1^tm1Agt
• Name: interferon gamma receptor 1; targeted mutation 1, Michel Aguet
• MGI ID: MGI:1857286
• Synonyms: G129, IFN-gamma R-, IFN-gammaR-, IFN-gammaR^-, IFN-gamma R⁰, IFN-gammaR⁰, IFN-gammaR1^-, IFN-gammaRalpha^_, IFN-gamma-R KO, IFN-gammaR KO, IFNgammaR KO, Ifngr-, Ifngr1^-, IFNgR KO, IFn type II receptor
• Gene: Ifngr1 Location: Chr10:19467697-19485977 bp, + strand Genetic Position: Chr10, 8.49 cM
• Alliance: Ifngr1^tm1Agt page

Trpm2^tm1.1Alp/Trpm2^tm1.1Alp and Ifngr1^tm1Agt/Ifngr1^tm1Agt mice exhibit increased susceptibility to bacterial infection

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63815
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor. (J:61321, J:63815, J:96036)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ifngr1^tm1Agt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 13 strains available Cell Lines: 0 lines available
• Carrying any Ifngr1 Mutation: 53 strains or lines available

References

• Original: J:63815 Huang S, et al., Immune response in mice that lack the interferon-gamma receptor [see comments]. Science. 1993 Mar 19;259(5102):1742-5
• All: 640 reference(s)