Cryge^t
Radiation induced Allele Detail

Summary

• Symbol: Cryge^t
• Name: crystallin, gamma E; total opacity and microphthalmia
• MGI ID: MGI:1857598
• Synonyms: Cat-2^t, Cat2^t, Cryge^Cat2-t, R-324
• Gene: Cryge Location: Chr1:65087713-65090308 bp, - strand Genetic Position: Chr1, 32.8 cM
• Alliance: Cryge^t page

Mutation origin

• Strain of Origin: (102/El x C3H/El)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: A C to G transversion at nucleotide position 432 in exon 3 of Cryge that creates a premature termination signal and results in a truncated protein after amino acid 143. (J:50319)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cryge Mutation: 25 strains or lines available

Notes

With the discovery that the mutation is a nucleotide substitution, it has been suggested that Cryge^Cat2-t may have possibly been spontaneous instead of X-ray induced J:50319.

Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous and homozygous mice mice (J:9528)

References

• Original: J:52633 Graw J, et al., Dominant cataract and recessive specific locus mutations in offspring of X-irradiated male mice. Mutat Res. 1986 Jan-Feb;159(1-2):47-54
• All: 8 reference(s)