Summary |
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Mutation origin |
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Mutation description |
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Tumor Data |
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Find Mice (IMSR) |
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Notes |
129 substrains, C57BL/6J and BTBR carry this inbred strain variant allele.
A mutation in the Apc gene of the mouse causes multiple intestinal adenomas in the C57BL/6J strain on which it arose. In crosses with other strains, the number of tumors is reduced. A locus controlling about 50% of genetic variation in tumor number has been identified as Pla2g2a. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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