Map3k14^aly
Spontaneous Allele Detail

Summary

• Symbol: Map3k14^aly
• Name: mitogen-activated protein kinase kinase kinase 14; alymphoplasia
• MGI ID: MGI:1858522
• Synonyms: aly, nik^aly
• Gene: Map3k14 Location: Chr11:103110590-103158227 bp, - strand Genetic Position: Chr11, 66.8 cM
• Alliance: Map3k14^aly page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-A transition point mutation resulted in a replacement of a conserved glycine with an arginine at position 855 of the encoded protein (p.G855R). (J:54529)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Map3k14 Mutation: 41 strains or lines available

References

• Original: J:16865 Miyawaki S, et al., A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol. 1994 Feb;24(2):429-34
• All: 102 reference(s)