Apaf1^tm1Her
Targeted Allele Detail

Summary

• Symbol: Apaf1^tm1Her
• Name: apoptotic peptidase activating factor 1; targeted mutation 1, Joachim Herz
• MGI ID: MGI:1860245
• Synonyms: Apaf1^-
• Gene: Apaf1 Location: Chr10:90825173-90918632 bp, - strand Genetic Position: Chr10, 45.47 cM, cytoband C3-D1
• Alliance: Apaf1^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60409
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin casette into sequences encoding the Ced 4 homology domain corresponding to amino acid 111. Insertion disrupts the reading frame of the protein. (J:60409)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apaf1 Mutation: 78 strains or lines available

References

• Original: J:60409 Honarpour N, et al., Adult Apaf-1-deficient mice exhibit male infertility. Dev Biol. 2000 Feb 15;218(2):248-58
• All: 13 reference(s)