Lop4
Chemically induced Allele Detail

Summary

• Symbol: Lop4
• Name: lens opacity 4
• MGI ID: MGI:1861143
• Gene: Lop4 Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Lop4 page

Mutation origin

• Strain of Origin: (PT x C3H/HeH)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lop4 Mutation: 0 strains or lines available

Notes

Six mice with inherited cataracts were found among the F1 offspring of C3H/HeH males that had been treated with ethylnitrosourea. Five of the original F1 animals showed very similar phenotypes, with cataracts of variable severity that involved clusters or arcs of reflectant specks in the nuclear or perinuclear region. The mutations in these mice were designated Lop4 through Lop8. The sixth mutant showed an abnormality in the anterior cortex region; this mutation was labeled Lop9. Penetrance in F1 heterozygotes is probably incomplete. Homozygotes have not been positively identified, but mice with bright white nuclear cataracts were found only in progeny of crosses that could have produced homozygous offspring (J:8242).

References

• Original: J:64438 West JD, et al., Lop4, Lop5, Lop6, Lop7, Lop8, Lop9 - lens opacity. Mouse News Lett. 1985;72:105-6
• All: 2 reference(s)