Crygs^Opj
Chemically induced Allele Detail

Summary

• Symbol: Crygs^Opj
• Name: crystallin, gamma S; opacity due to poor secondary fiber cell junctions
• MGI ID: MGI:1861635
• Synonyms: ENU-410
• Gene: Crygs Location: Chr16:22623953-22630160 bp, - strand Genetic Position: Chr16, 13.66 cM
• Alliance: Crygs^Opj page

Progressive cataract development in Crygs^Opj/Crygs⁺ and Crygs^Opj/Crygs^Opj mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (101 x C3H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single base pair mutation (T to C) in exon 2 replaces Phe with Ser at amino acid position 9 of the protein. The mutant protein shows a concentration dependent decrease in solubility and a loss of secondary structure at near-physiological temperatures. (J:68109)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Crygs Mutation: 44 strains or lines available

References

• Original: J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
• All: 5 reference(s)