Ccr5^tm1Kuz
Targeted Allele Detail

Summary

• Symbol: Ccr5^tm1Kuz
• Name: C-C motif chemokine receptor 5; targeted mutation 1, William A Kuziel
• MGI ID: MGI:1861911
• Synonyms: CCR5-, CCR5 KO, Cmkbr5^tm1Kuz
• Gene: Ccr5 Location: Chr9:123921557-123934153 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr5^tm1Kuz page

Ccr5^tm1Kuz/Ccr5^tm1Kuz and wild-type littermates underwent bile duct ligation or sham operation. Macrophage infiltration was determined by immunohistochemistry for F4/80

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64293
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon containing the entire coding region was replaced with a neomycin resistance gene inserted by homologous recombination. (J:84243)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccr5 Mutation: 31 strains or lines available

References

• Original: J:64293 Huffnagle GB, et al., Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol. 1999 Nov 1;163(9):4642-6
• All: 193 reference(s)