C4b^tm1Crr
Targeted Allele Detail

Summary

• Symbol: C4b^tm1Crr
• Name: complement C4B (Chido blood group); targeted mutation 1, Michael C Carroll
• MGI ID: MGI:1889070
• Synonyms: C4-
• Gene: C4b Location: Chr17:34947354-34962856 bp, - strand Genetic Position: Chr17, 18.29 cM
• Alliance: C4b^tm1Crr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30152
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment corresponding to 987 nucleotides of coding sequence (exons 23-29) was replaced with a neomycin selection cassette. ELISA assays on serum derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:64282)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any C4b Mutation: 103 strains or lines available

References

• Original: J:30152 Wessels MR, et al., Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11490-4
• All: 90 reference(s)