Myo6^Mhdatlc
Chemically induced Allele Detail

Summary

• Symbol: Myo6^Mhdatlc
• Name: myosin VI; Martin Hrabe de Angelis tailchaser
• MGI ID: MGI:1913078
• Synonyms: ABE1, Myo6^Tlc, tailchaser, Tlc
• Gene: Myo6 Location: Chr9:80072313-80219011 bp, + strand Genetic Position: Chr9, 43.98 cM
• Alliance: Myo6^Mhdatlc page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Sequencing of cDNA extracted and amplified from heterozygous brains revealed a G to T substitution at coding cDNA nucleotide 535 (c.535G>T) in a region that corresponds to exon 7 (coding exon 6) of the gene. This mutation results in an aspartic acid to tyrosine amino acid substitution at the highly conserved position 179 of the encoded protein (p.D179Y or p.Asp179Tyr). (J:161272)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Myo6 Mutation: 91 strains or lines available

References

• Original: J:64900 Kiernan AE, et al., Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival. J Neurocytol. 1999 Oct-Nov;28(10-11):969-85
• All: 2 reference(s)